Catalyst-Free Domino Cross-Olefinations and Intramolecular Cyclizations of Morita–Baylis–Hillman Carbonates with Sulfur Ylides

Abstract

A novel strategy for the catalyst-free domino crossolefination and intramolecular cyclization of Morita−Baylis− Hillman carbonates with sulfur ylides has been established, resulting in the synthesis of 1,2-dihydroquinolines with a broad scope, excellent chemoselectivity, and high efficiency. Mechanistic experiments revealed the process of 1,1-dipole cross-olefination and highlighted the assistance of the amino group in achieving successful transformations.1,1-Dipoles are designed, synthesized, and applied in [1+n] dipolar cycloadditions (Scheme 1A), notably including the