Catalyst-free efficient synthesis of polyhydroquinolines using polyethylene glycol as a solvent and evaluation of their cytotoxicity

Solvent‐Free Hantzsch Condensation Reaction Leading to Polyhydroquinoline and 1,8‐Dioxo‐decahydroacridine Derivatives Promoted by Nanosized Kaolin‐[BTMSP]‐NH2+ HSO4−

“…However, this classic process suffers from several disadvantages, such as long reaction time, use of a large quantity of volatile organic solvents and low yield. [1,9] Since then, a large number of catalysts such as Fe 3 O 4 -adenine-Ni, [10] L-proline, [11,12] ED/MIL-101(Cr), [13] molecular iodine, [14] Yb-(OTf) 3 , [15] ceric Ammonium Nitrate, [16] K 7 [PW 11 CoO 40 ], [17] ZnO, [18] glycine, [19] PPA-SiO 2 , [20] FeF 3 , [21] Cd(NO 3 ) 2 .4H 2 O, [22] polyethylene glycol, [23] ChCl/urea, [24] nano-γ-Fe 2 O 3 -SO 3 H, [25] IRMOF-3, [4] Ga 2 O 3, [26] SBA-15@AMPDÀ Co, [27] nicotinic acid, [28] Nidithizone@boehmite, [29] TEDETA@BNPs, [30] ascorbic acid, [31] La 3 + / 4A, [32] Fe 3 O 4 @B-MCM-41, [33] and BiBr 3 [34] have been used to improve the Hantzsch reaction conditions. Although each of the reported catalysts and techniques has its advantages, nevertheless further efforts are needed to introduce more efficient and cleaner catalytic systems for the synthesis of the above mentioned important target molecules.…”

Synthesis and antitumor evaluation of some new thiazolopyridine, nicotinonitrile, pyrazolopyridine, and polyhydroquinoline derivatives using ceric ammonium nitrate as a green catalyst

“…[ 41 ] Also, pyridine is widely distributed in many biological molecules, and found in drugs such as nifedipine. [ 42 ] The other important species containing pyridine and thiazolidinone moieties are rosiglitazone and pioglitazone, [ 43 ] which act as type‐2 diabetes drugs. [ 44 ] These pharmaceutical drugs act as binders to the peroxisome proliferator‐activated receptors that upon activation migrate to the DNA to regulate the transcription of specific genes that control the metabolism of carbohydrates and fatty acids.…”

Evaluation of the antioxidant activities of fatty polyhydroquinolines synthesized by Hantzsch multicomponent reactions

“…[7][8][9] In recent years, much consideration has been given to the synthesis of the PHQ derivatives because of their pharmacological signicance, which makes them potential targets for a number of biological applications. [10][11][12][13] However, the important results around these small biologically active molecules have inspired further research to identify new, similar substances with diverse structures and to better understand the relationship between the variation in the chemical structure and biological activity.…”