Catalyst-free synthesis of isoxazolidine from nitrosoarene and haloalkyne via a 1,2-halo-migration/[3 + 2] cycloaddition cascade

Abstract

An unprecedented catalyst-free three-component reaction to synthesize isoxazolidine from easily accessible haloalkyne, nitrosoarene and maleimide was developed. This reaction was proposed to proceed via 1, 2-halo migration and [3+2] cycloaddition...

Aerobic oxidation/metal-free cyclization cascades of nitrosoarenes and allenynes with TEMPO/O2: a switch of diradical to single radical intermediates

“…Nitrosoarenes are well-recognized to possess hidden diradical character 6–8 for the synthesis of N , O -functionalized heterocycles from their metal-catalyzed reactions with alkynes 6,7 or alkenes. 8 Recently, we reported metal-free annulations of one arylallene with two discrete nitrosoarenes to deliver cyclic nitroxy ring products.…”