2024
DOI: 10.1021/acs.joc.4c00280
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Catalytic 2-Ethylhexanoic Acid Promotes Mild Miyaura Borylations

Brittany M. Klootwyk,
J. Craig Ruble,
Graham R. Cumming
et al.

Abstract: The Miyaura borylation of aryl and heteroaryl chlorides and bromides using a combination of potassium carbonate and 5 mol % 2-ethylhexanoic acid at 25 °C is reported. The in situ generation of a catalytic amount of potassium 2-ethylhexanoate under these conditions avoids the need for special handling of stoichiometric quantities of hygroscopic potassium 2-ethylhexanoate during the reaction setup as well as difficulties in removing the resulting carboxylic acid during product isolation.

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