Catalytic and Immunochemical Characterization of Hepatic Microsomal Cytochromes P450 in Beluga Whale (Delphinapterus leucas)

White, Renee D.; Hahn, Mark E.; Lockhart, W.L.; Stegeman, John J.

doi:10.1006/taap.1994.1089

Cited by 118 publications

(97 citation statements)

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“…PCB residue patterns in cetaceans suggest that CYP2B-type enzyme activity is low (Duinker et al, 1989;Tanabe et al, 1988;Norstrom et al, 1992). Low rates of metabolism of 2,2',5,5'-tetraCB (CB-52) in pilot and beluga whale and low rates of CYP2B-activities in beluga also support this hypothesis (White et al, 1994(White et al, , 2000. In grey seals, CYP1-, CYP2-, and CYP3-like enzymes are expressed in liver and extrahepatic tissues (Nyman et al, 2000), and CYP1A-and CYP3A-like enzymes are involved in the metabolism of mono-ortho PCB congeners (such as CB-105 and -118) (Li et al, 2003).…”

Section: -Oh-cb146 3'-oh-cb138 4-oh-cb163 4-oh-cb178 and 4'-oh-cmentioning

confidence: 99%

Organohalogen contaminants and metabolites in cerebrospinal fluid and cerebellum gray matter in short-beaked common dolphins and Atlantic white-sided dolphins from the western North Atlantic

Montie

Reddy

Gebbink

et al. 2009

Environmental Pollution

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Section: -Oh-cb146 3'-oh-cb138 4-oh-cb163 4-oh-cb178 and 4'-oh-cmentioning

confidence: 99%

Organohalogen contaminants and metabolites in cerebrospinal fluid and cerebellum gray matter in short-beaked common dolphins and Atlantic white-sided dolphins from the western North Atlantic

Montie

Reddy

Gebbink

et al. 2009

Environmental Pollution

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“…Farland and Clarke, 1989 . However, the PCB pattern also reflects the specific metabolic capacity of cetaceans to metabolize these compounds ŽTanabe et al, 1988;Norstrom et al, 1992;White . et al, 1994;Goksøyr, 1995 .…”

Section: ( )mentioning

confidence: 99%

Concentrations and patterns of organochlorine contaminants in white whales (Delphinapterus leucas) from Svalbard, Norway

Andersen

Kovacs

Lydersen

et al. 2001

Science of The Total Environment

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Ž. Blubber was collected from live-captured, adult male white whales Delphinapterus leucas from Svalbard, Norway, Ž . and analysed for levels and patterns of organochlorine OC contaminants. The OC compounds analysed were HCB, Ž . Ž dieldrin, ⌺HCH ␣-HCH, ␤-HCH and ␥-HCH , ⌺Chl heptachlor epoxide, oxychlordane, cis-chlordane, trans-non-. Ž . Ž . achlor, and cis-nonachlor , ⌺DDT ppЈ-DDT, ppЈ-DDE and ppЈ-DDD and ⌺PCB 27 PCB congeners . The major Ž . Ž . OC compounds detected in the blubber were ⌺PCB 5103 " 1874 ngrg l.w. and ⌺DDT 5108 " 1089 ngrg l.w. , Ž . which made up 70% of the ⌺OC. These compounds were followed in prevalence by ⌺Chl 2872 " 1177 ngrg l.w. , which contributed 20% of the ⌺OC burden. ⌺HCH, HCB and dieldrin were present, but at low concentrations. This OC pattern is typical of top predators in Arctic marine food chains. OC levels in white whales from Svalbard are lower than white whales from the St Lawrence River in Canada and are generally similar to values reported previously for other Arctic white whale stocks. Some geographic patterns in relative prevalence of various OC compounds appear to be quite consistent among various marine mammal species in the Arctic. PCB and DDT concentrations in Svalbard's white whales are below the levels that are thought to have negative effects on reproduction or the immune system. ᮊ

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“…Although the ability to metabolise PCBs was previously thought to be less well developed in cetaceans than in pinnipeds (Boon et al, 1997), implying that cetaceans may be more sensitive to effects of exposure to POPs, more recent evidence (reviewed by Hall et al, 2006) suggests that this may not be the case. Immunoreactive proteins recognised by heterologous CYP2B antibodies are present in several cetaceans including harbour porpoises (White et al, 1994;Goksøyr, 1995;Hummert et al, 1995) and CYP1B-like amino acid sequences are present in striped dolphin cDNA (Godard et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Bioaccumulation of persistent organic pollutants in female common dolphins (Delphinus delphis) and harbour porpoises (Phocoena phocoena) from western European seas: Geographical trends, causal factors and effects on reproduction and mortality

Pierce

Santos

Murphy

et al. 2008

Environmental Pollution

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High PCB levels were recorded in porpoises and common dolphins from European coasts. AbstractConcentrations of polychlorinated biphenyls (PCBs) in blubber of female common dolphins and harbour porpoises from the Atlantic coast of Europe were frequently above the threshold at which effects on reproduction could be expected, in 40% and 47% of cases respectively. This rose to 74% for porpoises from the southern North Sea. PCB concentrations were also high in southern North Sea fish. The average pregnancy rate recorded in porpoises (42%) in the study area was lower than in the western Atlantic but that in common dolphins (25%) was similar to that of the western Atlantic population. Porpoises that died from disease or parasitic infection had higher concentrations of persistent organic pollutants (POPs) than animals dying from other causes. Few of the common dolphins sampled had died from disease or parasitic infection. POP profiles in common dolphin blubber were related to individual feeding history while those in porpoises were more strongly related to condition.

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Catalytic and Immunochemical Characterization of Hepatic Microsomal Cytochromes P450 in Beluga Whale (Delphinapterus leucas)

Cited by 118 publications

References 0 publications

Organohalogen contaminants and metabolites in cerebrospinal fluid and cerebellum gray matter in short-beaked common dolphins and Atlantic white-sided dolphins from the western North Atlantic

Organohalogen contaminants and metabolites in cerebrospinal fluid and cerebellum gray matter in short-beaked common dolphins and Atlantic white-sided dolphins from the western North Atlantic

Concentrations and patterns of organochlorine contaminants in white whales (Delphinapterus leucas) from Svalbard, Norway

Bioaccumulation of persistent organic pollutants in female common dolphins (Delphinus delphis) and harbour porpoises (Phocoena phocoena) from western European seas: Geographical trends, causal factors and effects on reproduction and mortality

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