Catalytic Asymmetric Polycyclization of Tertiary Enamides with Silyl Enol Ethers: Total Synthesis of (−)-Cephalocyclidin A

Asymmetric Intramolecular Amination Catalyzed with Cp*Ir-SPDO via Nitrene Transfer for Synthesis of Spiro-Quaternary Indolinone

“…Recently, our research group has successfully demonstrated the exceptional stereocontrol ability of chiral SPDO (spiro-pyrrolidine oxazoline) ligands in asymmetric coupling, hydroalkylation, and annulations upon coordination with Ni and Cu . Additionally, the Chang group has demonstrated a nonchiral Cp*Ir reagent as catalyst to enable the highly efficient amidation to electron-deficient α -C–H of β -keto esters using TrocN 3 .…”