Catalytic Asymmetric Synthesis of Quaternary Carbon Centers. Exploratory Investigations of Intramolecular Heck Reactions of (E)-α,β-Unsaturated 2-Haloanilides and Analogues To Form Enantioenriched Spirocyclic Products

Abstract

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Phosphoramidite: privilegierte Liganden in der asymmetrischen Katalyse

“…In diesem Zusammenhang ist eine intramolekulare decarboxylierende allylische Amidierung [298,[307][308][309] auf der Basis des Iridium/Phosphoramidit-Katalysatorsystem zu erwähnen (Schema 59). [310,311] …”

Recent applications of isatin in the synthesis of organic compounds

“…57 The unique structural array and the highly pronounced pharmacological activity displayed by the class of spirooxindole compounds have made them attractive synthetic targets ( Figure 1). [58][59][60] Figure 1 3.1. Synthesis involving two-component reactions of isatins 3.1.1.…”

Computational Studies and Energies for the Dioxa-Pentaazaheptacyclo-Hentriaconta-Octaen-One through Density Functional Theory and Natural Bond Orbital

“…For example, spirotryprostatin B, a natural alkaloid isolated from the fermentation broth of aspergillus fumigatus, has been identified as a novel inhibitor of microtubule assembly, and pteropodine and isopteropodine have been shown to modulate the function of muscarinic serotonin receptors. The interesting structural array and the highly pronounced pharmacological activity displayed by the class of spirooxindole compounds have made them attractive synthetic compounds [13][14][15][16]. Azaspiro derivatives are well-known [17][18][19], but the preparation of the corresponding oxa analogues has evolved at a relatively slow pace [20].…”