Catalytic Asymmetric Transfer Hydrogenation of Ketones Using [Ru(p-cymene)Cl2]2 with Chiral Amino Alcohol Ligands

Abstract

Catalytic asymmetric transfer hydrogenation of aromatic alkyl ketones has been investigated using [Ru(pcymene)Cl 2 ] 2 and new derivatives of b-amino alcohols synthesized from (S)-(-)-lactic acid and mandelic acid as ligands. Chiral secondary alcohols were obtained with good to excellent conversion (60-90%) and moderate to good enantioselectivities (40-86%).

Ruthenium(II) complexes derived from C2‐symmetric ferrocene‐based chiral bis(phosphinite) ligands: synthesis and catalytic activity towards the asymmetric reduction of acetophenones

“…4‐Methoxyacetophenone is known to be a tough substituent probably because of its rather low redox potential, and it gives lower conversion and enantioselectivity . However, in the present work, the reduction of 2‐ or 4‐methoxyacetophenone occurs with 98 or 97% conversion and 97 or 88% ee , respectively, at 82°C.…”

Redetermination of the crystal structure of 2-amino-2-methyl-propane-1,3-diole, C4H11NO2

“…While the unit cell dimensions of the aminole are apparent in the literature no 3D coordinates have been deposited [8]. The crystal and molecular structures of similar aminoles have been reported earlier [9][10][11][12][13][14][15][16].…”

Crystal structure of DL-α-(methylaminomethyl)benzyl alcohol, C9H13NO

“…At the beginning of a study about a series of homo-and heteroleptic coordination compounds derived from simple vicinal aminols, the title compound was chosen as it only features one hydrogen atom on the nitrogen atom which we deemed to limit and simplify the coordination behaviour of this ligand and because very similar aminoles have been found to form stable coordination compounds with copper [8][9][10]. The crystal and molecular structures of similar aminoles have been reported earlier [11][12][13][14][15][16][17][18].…”