Alkyl radicals generated via an acridine photocatalyzed
decarboxylation
reaction of feedstock carboxylic acids engage with a range of cyclic
imine–BF3 complexes to provide α-functionalized
azacycles in an operationally simple process. A three-component variant
of this transformation incorporating [1.1.1]propellane as an additional
reaction partner enables the synthesis of valuable bicyclopentane
(BCP)-containing azacycles. Reactions exhibit good functional group
compatibility, enabling late-stage modification of complex bioactive
molecules.