Catalytic effect of molecular iodine in the pyrrolization of tetramethoxytetrahydrofuran with optically active amines

Synthesis of N-alkoxycarbonyl Pyrroles from O-Substituted Carbamates: A Synthetically Enabling Pyrrole Protection Strategy

“…We have further shown the outcome of the acylation to be regioselective depending on the protecting group used, with N -alkoxycarbonyl- and N -sulfonyl pyrroles giving regioisomeric products (after deprotection). We anticipate the versatility of the N -alkoxycarbonyl pyrrole formation may be further increased by the use of substituted variants of 1 , as has been demonstrated for the original Clauson-Kaas process. ,− …”

“…We anticipate the versatility of the N -alkoxycarbonyl pyrrole formation may be further increased by the use of substituted variants of 1 , as has been demonstrated for the original Clauson-Kaas process. 7 , 39 − 49 …”