Catalytic Oxidation of Alcohols

Solvent-Free Microwave-Assisted Peroxidative Oxidation of Alcohols Catalyzed by Iron(III)-TEMPO Catalytic Systems

“…As expected [7,9], the alicyclic cyclohexanol is less reactive than 1-phenylethanol: Table 3, entries 1-3). The linear aliphatic alcohols, 2-hexanol and 3-hexanol, lead to even lower yields in the 45-56 % range (Table 3, entries 4-9), under similar reaction conditions, as reported in other cases [2,3,6,7]. The activity of 1-3 in the oxidation of benzyl alcohol or 1-hexanol is quite modest since only rather moderated yields of benzaldehyde (30-34 % range) or hexanal (22-24 % range) are obtained under the same reaction conditions (Table 3, entries 10-12 and 13-15, respectively).…”

“…The catalytic systems of the present study seem to operate under heterogeneous conditions and, although yielding ketone products in the range reported for homogeneous ones [2,3,6,7], e.g., the tris{2,4-bis(trichloromethyl)-1,3,5-triazapentadienato}-Fe(III) complexes/MW/TBHP systems [11], they are advantageous due to the possibility of recycle and reuse of the catalysts up to three consecutive catalytic cycles without a marked loss of activity (see below).…”

“…MW irradiation (10 W) provides a more efficient synthetic method than conventional heating, thus allowing the attainment of similar yields in shorter times, as observed in other cases [2,3]. For example, in the presence of 3, a 99.3 % yield of acetophenone was obtained after 1 h reaction under MW irradiation at 150°C, while the reaction under conventional heating (oil bath) gives only 9 % yield.…”

“…The oxidation of primary and secondary alcohols to carbonyl compounds is one of the most important reactions in synthetic organic chemistry, as well as in chemical industry [1][2][3]. Many catalytic methods have been developed for the oxidation of alcohols, the most commonly utilizing homogeneous catalysts based on different transition metals, such as Co [3], Mn [4,5], V [6], Cu [7][8][9][10], Fe [11][12][13][14], Mo [14], Ru [16,17], and Pd [18].…”

“…Many catalytic methods have been developed for the oxidation of alcohols, the most commonly utilizing homogeneous catalysts based on different transition metals, such as Co [3], Mn [4,5], V [6], Cu [7][8][9][10], Fe [11][12][13][14], Mo [14], Ru [16,17], and Pd [18]. Unfortunately, most of the Electronic supplementary material The online version of this article (doi:10.1007/s10562-015-1616-2) contains supplementary material, which is available to authorized users.…”