Catalytic properties of several supported Pd(II) complexes for Suzuki coupling reactions

Silica-supported palladium: Sustainable catalysts for cross-coupling reactions

“…Its importance is reflected in the immense economic value of pharmaceuticals including Valsartan [70,71] and Telmisartan [72,73], and agrochemicals such as Boscalid [74]. As alternatives to the homogeneous Pd-phosphine catalysts, Pd on carbon [75,76], on silica or polymer supports [77][78][79], and on mesoporous materials can be used [80,81]. Silica-supported Pd catalysts useful for Suzuki crosscoupling reactions can be prepared in various ways providing different structures and activity.…”

Organic–inorganic hybrid materials containing 15-membered azamacrocyclic triolefinic palladium(0) complexes

“…13 C NMR (62.5 MHz, CDCl 3 ): δ = 23. 9, 25.2, 29.6, 34.5, 44.2, 45.7, 47.0, 48.3, 48.9, 50.2, 79.1, 79.4, 83.7, 83.8, 84.0, 114.5, 124.3, 126.7, 129.7, 131.7, 150.9, 151.7 and 153.6 ,7.04;N,5.59;S,9.60. Found: C,57.53;H,7.23;N,5.49;S,9.31.…”

“…The crude mixture was purified by column chromatography (silica gel, hexane-ethyl acetate 6:3), affording 5aab as a white solid (0.47 g, 64%). 5, 24.8, 29.2, 34.1, 48.8, 51.2, 114.1, 123.9, 127.5, 129.2, 129.3, 130.8, 130.9, 150.5, 151.5 ,7.88;N,6.26. Found: C,63.90;H,7.65; N, 6.08.…”

One step synthesis of Diflunisal using a Pd-diamine complex

“…Although, Diflunisal has been prepared in one step by Suzuki coupling, excellent yield was obtained only by using a phosphine based catalyst, glovebox and degassed water (Scheme 5) [20]. Also, Felbinac has been prepared by Suzuki coupling using either phenylboronic acid [25,26] or tetraphenylborate [5,27] as reactant (Scheme 6). Suzuki coupling with free hydroxyl or carboxylic acid functionalities present in the aromatic halide have been reported but, aryltrifluoroborates, strong bases (KO t Bu, LiOH, KF), microwave or phosphine based palladium catalysts have been utilized [28][29][30][31][32][33].…”