Catalytic reduction of pralidoxime in pharmaceuticals by macrocyclic Ni(II) compounds derived from orthophthalaldehyde

Reddy, P. Muralidhar; Prasad, A. V. S. S.; Rohini, Rondla; Vadde, Ramakrishna

doi:10.1016/j.saa.2007.10.014

Cited by 20 publications

(26 citation statements)

References 36 publications

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“…[19][20][21][22][23][24][25][26][27] In this respect, we have also developed some useful macrocyclic Schiff bases and their metal complexes. Results from these studies have also shown that complexation of metals with Schiff base ligands serves to improve their antimicrobial activity.…”

Section: )mentioning

confidence: 99%

“…Thermal Analysis The thermograms of all the Co(II), Ni(II) complexes show three stages of decomposition, the first two corresponding to loss of water molecules and the third corresponding to decomposition of the complex with the loss of organic moiety. 19,21) The thermograms of Co(II)/Ni(II) complexes show initial weight loss in the temperature range of 90.4-104°C also the differential scanning calorimetry (DSC) curve of these complexes show an endothermic peak in the above temperature range further giving evidence for the presence of water molecules. The loss of water molecules in this temperature range indicates that they are present as lattice-held water.…”

Section: -27)mentioning

confidence: 99%

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Synthesis, Characterization and Biological Evaluation of Mononuclear Co(II), Ni(II), Cu(II) and Pd(II) Complexes with New N2O2 Schiff Base Ligands

Budige

Puchakayala

Kongara

et al. 2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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Schiff bases have a variety of applications in biological, clinical, and pharmacological areas. The synthesis and application of Schiff bases and their coordination compounds have been highly considered in inorganic, organic and biological fields, since their structural properties similar to some of the biological systems.1-6) Additionally, tetradentate Schiff bases composed of N 2 O 2 donor atoms set have been recognized as a kind of important chelating ligands for designing medicinally and catalytically useful metal complexes. [7][8][9] The flexible coordination behavior of these types of chelating ligands could also be useful to generate interesting dimeric and polymeric structures as synthones for supramolecular chemistry. 10,11) Usually, the N, O donor heterodentate Schiff bases can be derived by condensing the aldehydes/ketones with various amines or amino acids. 12,13) N 2 O 2 Schiff base ligands derived from salicylald ehyde and diamine have been known. 14,15) Dialdehydes and diketones with amines and amino acids have also been utilized to obtain a variety of N 2 O 2 Schiff base ligands. 16)Amino acids plays an important role in many physiological activities of the human body and also helpful in understanding biological functions of macromolecules such as proteins. 17) In particular, tryptophan (Trp)/histidine (His) analogues as promising candidates for novel antimicrobial therapeutics. In the recent years, a series of synthetic peptide analogues based on Trp-His and His-Arg (antimicrobial peptides) structural frameworks have been prepared and found to be active against several Gram-positive and Gram-negative bacterial strains as well as against fungal strains.18) Furthermore, it is well known that the human body contains essential metaloelements which play important roles and interact with many biological molecules to fully understand the physiological functions by studying their chemistry coordination and behavior. 17,18) In the present studies we have introduced an azomethine (Schiff base) linkage to tryptophan/histidine, which may permit a variety in their coordination behaviour and complexation role.In previous studies, we have described the synthesis, catalytic and biological applications of Schiff bases and their metal complexes derived from o-phthalaldehyde (OPA) with various amines. [19][20][21][22][23][24][25][26][27] In this respect, we have also developed some useful macrocyclic Schiff bases and their metal complexes. Results from these studies have also shown that complexation of metals with Schiff base ligands serves to improve their antimicrobial activity. There are few other research groups also reported the importance of Schiff base chemistry of the combination of o-phthalaldehyde with amines.28,29) However, a careful literature survey reveals that Schiff bases from the combination of amino acids and o-phthalaldehyde and their coordination behavior towards the transition elements have yet not been studied. The combination of dialdehyde i.e. o-phthalaldehyde and aminoacids is expected to ...

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Section: )mentioning

confidence: 99%

Section: -27)mentioning

confidence: 99%

Synthesis, Characterization and Biological Evaluation of Mononuclear Co(II), Ni(II), Cu(II) and Pd(II) Complexes with New N2O2 Schiff Base Ligands

Budige

Puchakayala

Kongara

et al. 2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…The peak at 2985 cm 1 and 3007 are attributed to the asymmetrical stretching (v as CH2) and symmetrical stretching (v s CH2).The high energy shifting of these peaks reflect strain in the chain. The symmetrical bending vibration (5 s CH 3 (Fig.…”

Section: Ir Spectra Of N2o2mentioning

confidence: 99%

“…The demi-macrocyclic are polydentate ligands with donor atoms commonly linked to a cyclic backbone. The macorcyclic ligands find vast and wide applications in chemical, biochemical and pharmacological [1] industrial laboratories. By virchue of their utility we report here the synthesis, and characterization of demi-macocyclic complexes of Co(II), Ni(II) and Cu(II) ions with donor ligand N 2 O 2 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral and Antimicrobal Studies of Demimacrocycles of Ligands N2O2 with Co(II), Ni(II) and Cu(II) Ions

Rasheed¹,

Dwivedi²,

Khan³

2018

International Journal of Advanced Research in Chemical Science

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“…[1][2][3][4][5] . During recent years macrocyclic chemistry has attracted much more attention, so it has become a growing class of research.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, and Spectral Studies of Demi-macrocycles of Ligand N2O2 with Ni (II) and Cu (II) Ions

2018

International Journal of Advanced Research in Chemical Science

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Catalytic reduction of pralidoxime in pharmaceuticals by macrocyclic Ni(II) compounds derived from orthophthalaldehyde

Cited by 20 publications

References 36 publications

Synthesis, Characterization and Biological Evaluation of Mononuclear Co(II), Ni(II), Cu(II) and Pd(II) Complexes with New N2O2 Schiff Base Ligands

Synthesis, Characterization and Biological Evaluation of Mononuclear Co(II), Ni(II), Cu(II) and Pd(II) Complexes with New N2O2 Schiff Base Ligands

Synthesis, Spectral and Antimicrobal Studies of Demimacrocycles of Ligands N2O2 with Co(II), Ni(II) and Cu(II) Ions

Synthesis, and Spectral Studies of Demi-macrocycles of Ligand N2O2 with Ni (II) and Cu (II) Ions

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