Cataract after allogeneic hematopoietic stem cell transplantation in childhood

Abstract

Lens opacities or cataract were more common in children or adolescents with malignant disease and after conditioning with irradiation. Regular ophthalmological follow-up is important after HSCT for early intervention to avoid amblyopia.

Visual perceptual skills and visual motor integration in children and adolescents after allogeneic hematopoietic stem cell transplantation

“…Main results from the ophthalmological examinations previously reported including best‐corrected visual acuity (BCVA) and detection of lens opacities/cataract were recalculated for this smaller cohort of 102 patients as the results could have a possible effect on outcome of the visual perceptual tests. BCVA was median 1.0 decimal (0.16‐1.6).…”

“…In a longitudinal study, ophthalmological examinations were performed in 139 children and adolescents (58 female, 81 male), who had undergone allogeneic HSCT at a single center at Karolinska University Hospital, Stockholm, between 1986 and 2012 . Data were collected during annual visits at the Department of the Pediatric ophthalmology, St. Erik Eye Hospital, Huddinge.…”

Visual evoked potentials after hematopoietic allogeneic stem cell transplantation in childhood

“…Patients were at a greater risk of developing cataract if conditioned with single fractio TBI (s-TBI) or fractionated TBI (f-TBI) when compared to busulfan or other chemotherapeutic drugs (Fahnehjelm et al, 2007). Poorer visual fields outcomes were found in patients who had undergone HSCT compared with normal controls (Tornquist et al, 2011) and long term results have been published (Tear Fahnehjelm et al, 2016). …”

“…(Tear Fahnehjelm et al, 2016) and encephalopathy (Shah, 1999, Noe et al, 2010) as well as CNS abnormalities visible on magnetic resonance imaging (MRI) or computerized tomography (CT) scans (Trullemans et al, 2001, Bartynski et al, 2004). …”

“…Ocular complications reported in children treated with TBI and or chemotherapy are cataract (Locatelli et al, 1993, De Marco et al, 1996, Suh et al, 1999, Holmstrom et al, 2002, Fahnehjelm et al, 2007, Tear Fahnehjelm et al, 2016), and dry eyes (Locatelli et al, 1993, Fahnehjelm et al, 2008, Ayuso et al, 2013, Kinori et al, 2015). Retinal haemorrhages, optic disc oedema, and chorioretinal lesions have also been described in children receiving TBI (Ayuso et al, 2013).…”