2019
DOI: 10.4239/wjd.v10.i3.140
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Cataract in diabetes mellitus

Abstract: Diabetes mellitus (DM) is a chronic systemic disease that has increases in prevalence over time. DM can affect all ocular structures, with cataract being the most common ocular complication. Cataract is the leading cause of blindness worldwide. Due to several mechanisms, there is an increased incidence of cataract formation in the diabetic population. Advancements in technology have now made cataract surgery a common and safe procedure. However, the diabetic population is still at risk of vision-threatening co… Show more

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Cited by 202 publications
(180 citation statements)
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“…Cataract symptoms mature earlier in DM patients than in other populations (Peterson et al, 2018). Different types of mechanisms have been proposed for the pathogenesis of cataract caused by DM, such as the polyol pathway, osmotic stress, OS and autoimmunity (Kiziltoprak et al, 2019). Cataract surgery is a common therapeutic strategy; however, unsuccessful surgery increases intraocular inflammatory cytokines (Kelkar et al, 2018).…”
Section: Diabetic Ocular Complicationsmentioning
confidence: 99%
“…Cataract symptoms mature earlier in DM patients than in other populations (Peterson et al, 2018). Different types of mechanisms have been proposed for the pathogenesis of cataract caused by DM, such as the polyol pathway, osmotic stress, OS and autoimmunity (Kiziltoprak et al, 2019). Cataract surgery is a common therapeutic strategy; however, unsuccessful surgery increases intraocular inflammatory cytokines (Kelkar et al, 2018).…”
Section: Diabetic Ocular Complicationsmentioning
confidence: 99%
“…[27] The hyperglycemic status leads to the additional production of sorbital from the Polyol pathway for glucose metabolism in lens. [18] Due to elevated osmotic pressure caused by the build-up of sorbital, [27] the excess fluid influx the lens which lead to cell swelling, membrane impairment and following cataract. [18] On the other hand, the DR would lead to an intraocular condition of hypoxia, ischemia and inflammation.…”
Section: Discussionmentioning
confidence: 99%
“…[18] Due to elevated osmotic pressure caused by the build-up of sorbital, [27] the excess fluid influx the lens which lead to cell swelling, membrane impairment and following cataract. [18] On the other hand, the DR would lead to an intraocular condition of hypoxia, ischemia and inflammation. [24] In the previous review article concerning PDR, the reactive oxygen spices, inflammatory cytokines and vascular endothelial growth factors were increased in the vitreous cavity, [28] and the oxidative stress is also the risk factors of cataract formation according to preceding laboratory studies.…”
Section: Discussionmentioning
confidence: 99%
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