Cataract Surgery with Primary Lens Implantation in Children with Chronic Uveitis

Guindolet, Damien; Dureau, P.; Terrada, C.; Edelson, C.; Barjol, Amandine; Caputo, G.; LeHoang, Phuc; Bodaghi, Bahram

doi:10.1080/09273948.2016.1213855

Cited by 15 publications

(32 citation statements)

References 28 publications

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“…Taken together, studies found that cataract surgery, regardless of IOL implantation, generally improved vision. Nearly all studies specifically highlighted the need for intensive immunosuppressive treatment and control of uveitis after cataract surgery, but it was unclear whether it was a question of sustaining preexisting regimen or based on a change in the need for controlling the uveitis [16,20,21,[32][33][34][35][36].…”

Section: Results Of Individual Studies and Risk Of Bias Within Studiesmentioning

confidence: 99%

“…Risk of bias assessment was challenged in three studies since we only had access to conference abstracts with limited information [30][31][32]. Remaining studies had moderate-toserious risk of bias (Table 4), in which the key source of bias was the baseline confounding from the fact that the allocation to either IOL implantation or aphakia across studies was based on the individual surgeon's estimation of whether or not pseudophakia or aphakia would benefit the patient best.…”

Section: Results Of Individual Studies and Risk Of Bias Within Studiesmentioning

confidence: 99%

“…Nine studies provided eligible and comparable data for the meta-analyses [16,20,21,30,[32][33][34][35][36]. ese studies collectively summarized data on 256 eyes: 153 eyes underwent IOL implantation and 103 eyes were aphakic.…”

Section: Synthesis Of Results In Meta-analyses and Risk Of Bias Across Studiesmentioning

confidence: 99%

“…e 10 studies collectively summarized data on 202 patients (Table 1). ree studies were only available as conference abstracts [30][31][32]. All were nonrandomized studies comparing groups obtained through retrospective chart reviews.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…ree studies do not report on the degree of preoperative inflammation [30,31,37] and two studies operated all eyes despite active inflammation [16,20].…”

Section: Study Characteristicsmentioning

confidence: 99%

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Cataract Surgery with or without Intraocular Lens Implantation in Pediatric Uveitis: A Systematic Review with Meta-Analyses

Schmidt

Al‐Bakri

Rasul

et al. 2021

Journal of Ophthalmology

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Purpose. To systematically review the results of comparative studies of modern cataract surgery in pediatric uveitis with or without intraocular lens (IOL) implantation and to perform comparative meta-analyses to compare visual acuity outcomes and complication rates. Methods. On 12 November 2020, we systematically searched the Cochrane Central, PubMed/MEDLINE, EMBASE, ClinicalTrials.gov, and all affiliated databases of the Web of Science. Two authors independently reviewed studies and extracted data. Studies were reviewed qualitatively in text and quantitatively with meta-analyses. Outcome measures were preoperative and postoperative best-corrected visual acuity (BCVA), inflammation control, and rates of postoperative complications. Results. Ten studies of 288 eyes were eligible for review of which the majority were eyes with juvenile idiopathic arthritis-associated uveitis. Summary estimates revealed that the BCVA was better in pseudophakic eyes vs. aphakic eyes (1-year postoperative: −0.23 logMAR, 95% CI: −0.43 to −0.03 logMAR, P = 0.027 ; 5-year postoperative: −0.35 logMAR, 95% CI: −0.51 to −0.18 logMAR, P = 0.000036 ). Pseudophakic eyes had more visual axis opacification (OR 6.76, 95% CI: 2.73 to 16.8, P = 0.000036 ) and less hypotony (OR 0.19, 95% CI: 0.04 to 0.95, P = 0.044 ). Conclusions. In modern era cataract surgery on eyes with pediatric uveitis with IOL implantation leads to satisfactory and superior visual outcomes and no differences in complication rates apart from an increased prevalence of visual axis opacification and a decreased prevalence of hypotony when compared to aphakia. However, limitations of the retrospective design and the presence of selection bias necessitate a careful interpretation.

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Section: Results Of Individual Studies and Risk Of Bias Within Studiesmentioning

confidence: 99%

Section: Results Of Individual Studies and Risk Of Bias Within Studiesmentioning

confidence: 99%

Section: Synthesis Of Results In Meta-analyses and Risk Of Bias Across Studiesmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

“…ree studies do not report on the degree of preoperative inflammation [30,31,37] and two studies operated all eyes despite active inflammation [16,20].…”

Section: Study Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations