Cataracts Associated with Allopurinol Therapy

Fraunfelder, Frederick T.; Hanna, Calvin; Dreis, Michael W.; Cosgrove, Kingsley W.

doi:10.1016/0002-9394(82)90067-8

Cited by 42 publications

(9 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased XO activity in cataractous lenses was previously reported [33]. There are also some reports about the possible relationship between cataractogenesis and chronic ingestion of allopurinol, the inhibitor of XO [34,35]. In this study, significantly increased XO activity in diabetic rat lenses occurred.…”

Section: Discussionsupporting

confidence: 67%

Superoxide Dismutase, Catalase, Glutathione Peroxidase and Xanthine Oxidase in Diabetic Rat Lenses

et al. 1999

View full text Add to dashboard Cite

The activities of the protective enzymes, superoxide dismutase, catalase, glutathione peroxidase and of xanthine oxidase, an enzyme acting as a source of O^–₂, were measured in the lenses of alloxan-induced diabetic and control rats. Superoxide dismutase and glutathione peroxidase activities were found to be significantly decreased, while catalase and xanthine oxidase activities were increased. This means that the ratio of the oxidant/antioxidant enzymes increases in the diabetic rat lens, suggesting an increased oxidative stress. This imbalance is possibly an important contributing factor in the pathogenesis of diabetic cataract.

show abstract

Section: Discussionsupporting

confidence: 67%

Superoxide Dismutase, Catalase, Glutathione Peroxidase and Xanthine Oxidase in Diabetic Rat Lenses

et al. 1999

View full text Add to dashboard Cite

show abstract

“…[27] The cataractogenic potential of allopurinol, especially for cortical cataracts (CCs) and posterior subcapsular cataracts (PSCs) development, has been suggested in some reports. [28] The cataracts associated with this antihyperuricemic agent have been found to initially occur in the form of anterior and posterior lens capsule changes with anterior subcapsular vacuoles. Over time, wedge-shaped anterior and posterior cortical haze occurs and dense posterior subcapsular cataracts develop.…”

Section: Discussionmentioning

confidence: 99%

“…Over time, wedge-shaped anterior and posterior cortical haze occurs and dense posterior subcapsular cataracts develop. [28] Liu et al [27] reported that unusual morphological thinning of the anterior clear zone of the lens may be observed in gout patients on long-term allopurinol therapy. In addition, clinical data suggest that there may be an association between the development of anterior subcapsular cataracts and thinning of the anterior clear zone.…”

Section: Discussionmentioning

confidence: 99%

The association between gout and cataract risk: A meta-analysis

et al. 2017

View full text Add to dashboard Cite

PurposeTo evaluate the relationship between gout and age-related cataracts (ARCs).MethodsA comprehensive literature search of the PubMed and Web of Science databases was conducted to identify papers on the association between gout and cataract risk that had been published between February 1991 and January 2017. Pooled relative risks (RRs) or odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated. The random-effects model was used instead of the fixed-effects model when heterogeneity was identified, as indicated by a Cochran’s Q statistic P-value <0.10 or I2 index score >50%.ResultsA total of 3 cross-sectional studies and 3 case-control studies were included in the meta-analysis. Gout was significantly associated with increased odds of ARCs (OR 1.53, 95% CI 1.27–1.84). In the subgroup analysis, gout exhibited positive associations with the odds of posterior subcapsular cataracts (PSCs, OR 1.69, 95% CI: 1.06–2.70) and cortical cataracts (CCs, OR 1.39, 95% CI: 1.06–1.81). However, no association was identified between gout and the odds of nuclear cataracts.ConclusionsThe current literature suggested that gout may be associated with increased odds of ARCs, especially PSCs and CCs. Further efforts should be made to confirm these findings and clarify the effect of gout and gout medications on the development of cataracts.

show abstract

“…The results of our study suggest that long-term use of allopurinol increases the risk of cataract extraction in elderly patients. An elevated risk has been indicated equally by some clinical and experimental observations, [2][3][4]7 whereas most epidemiologic studies failed to find an increased risk. 5,6 One of these studies had a limited sample size and may therefore have lacked power to detect an increased risk.…”

Section: Commentmentioning

confidence: 99%

“…In 1982, Fraunfelder et al 2 reported 30 cases of cortical and subcapsular cataracts associated with long-term use of allopurinol that had been reported to the National Registry of Drug-Induced Ocular Side Effects (Oregon Health Sciences University, Portland). The observed lens changes appeared to have the characteristics of early age-related cataracts.…”

mentioning

confidence: 99%

Exposure to Allopurinol and the Risk of Cataract Extraction in Elderly Patients

Garbe¹

1998

Arch Ophthalmol

View full text Add to dashboard Cite

To determine whether exposure to allopurinol is associated with an increased risk of cataract extraction in elderly patients. Methods: We conducted a case-control study using data from the Quebec universal health insurance program for all elderly patients. The 3677 cases were patients with a cataract extraction between 1992 and 1994. The 21 868 controls were randomly selected among patients not diagnosed with cataract and matched to cases on the date of the extraction. We determined the odds ratio of cataract extraction according to the cumulative dose and duration of allopurinol use relative to nonusers, using conditional logistic regression analysis. The analysis was adjusted for the effects of age, sex, diabetes melli-tus, hypertension, glaucoma, and ophthalmic and oral corticosteroid exposure. Results: A cumulative dose of allopurinol of more than 400 g or a duration of use of longer than 3 years were associated with an increased risk of cataract extraction, with odds ratios of 1.82 (95% confidence interval [CI], 1.18-2.80) and 1.53 (95% CI, 1.12-2.08), respectively. No increase in risk was observed for lower cumulative doses or shorter exposure periods. Conclusion: Long-term administration of allopurinol increases the risk of cataract extraction in elderly patients.

show abstract

Cataracts Associated with Allopurinol Therapy

Cited by 42 publications

References 6 publications

Superoxide Dismutase, Catalase, Glutathione Peroxidase and Xanthine Oxidase in Diabetic Rat Lenses

Superoxide Dismutase, Catalase, Glutathione Peroxidase and Xanthine Oxidase in Diabetic Rat Lenses

The association between gout and cataract risk: A meta-analysis

Exposure to Allopurinol and the Risk of Cataract Extraction in Elderly Patients

Contact Info

Product

Resources

About