Cataracts, glaucoma, and femoral avascular necrosis caused by topical corticosteroid ointment

McLean, Chris; Lobo, Renata Ferreira; Brazier, D J

doi:10.1016/s0140-6736(95)90324-0

Cited by 46 publications

(25 citation statements)

References 3 publications

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“…In our patient, the two events occurred at almost the same time despite his longterm use of topical corticosteroid ointments. In the patient with the double events reported by McLean et al [7], the eye symptoms occurred initially, and the hip symptoms occurred subsequently, within a year, similar to the timing in our patient. We do not know why both pathological events occurred at almost the same time in our patient, but the cumulative effects of corticosteroid use may have played a role in the development of both lesions.…”

Section: Discussionsupporting

confidence: 88%

“…However, this problem is usually associated with oral administration or IV injection, and it is quite rare with topical corticosteroid application. Several hips have been reported as showing ONFH following the use of topical corticosteroid ointments [4][5][6][7][8][9][10]; Cunliffe et al [4] first reported two cases of 2 hips in 1975. However, these reports included patients with a medical history of systemic corticosteroid therapy as well as topical corticosteroid treatment or a history of alcohol abuse.…”

Section: Discussionmentioning

confidence: 99%

“…Periocular corticosteroid ointments are known to cause glaucoma. The first report, from Hales [11], was followed by reports of several other cases [7,[11][12][13]. But the occurrence of both ONFH and glaucoma following the use of topical corticosteroids has been reported only by McLean et al [7].…”

Section: Discussionmentioning

confidence: 99%

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Osteonecrosis of the femoral head and glaucoma caused by topical corticosteroid application

Kabata

Shimanuki

et al. 2011

Mod Rheumatol

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A 37-year-old man was diagnosed with bilateral osteonecrosis of the femoral head (ONFH) and glaucoma. He had no risk factors for either ONFH or glaucoma, except for 24 years' continuous use of topical corticosteroid ointments for treating atopic dermatitis. We determined that the topical steroid had caused both the pathological conditions. It is necessary to recognize that continuous topical corticosteroid therapy may cause the same pathological conditions as those caused by the systemic administration of these agents.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Osteonecrosis of the femoral head and glaucoma caused by topical corticosteroid application

Kabata

Shimanuki

et al. 2011

Mod Rheumatol

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“…Using a similar design, Saripalli et al have shown that tacrolimus ointment 0.1% is effective in allergic contact eczema caused by nickel [17] . These results are especially relevant to patients who have chronic forms on the face or on the eyelid for which topical corticosteroids cannot be used long-term because of the risk of skin atrophy and increased ocular pressure [18] .…”

Section: Contact Eczemamentioning

confidence: 99%

Potential New Indications of Topical Calcineurin Inhibitors

Luger

Paul

2007

Dermatology

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The topical calcineurin inhibitors pimecrolimus (Elidel®) and tacrolimus (Protopic®) were initially developed for the treatment of atopic eczema (atopic dermatitis), a chronic or chronically relapsing skin condition most prevalent in infants and children. Their main advantages compared with conventional topical corticosteroid therapy are that they are more selective in their mode of action, do not induce skin atrophy and are not associated with significant systemic absorption. In addition, topical calcineurin inhibitors may represent a useful alternative to topical corticosteroids for the treatment of a number of other inflammatory skin diseases. Preferred sites for the use of topical calcineurin inhibitors are areas such as the face, neck, flexures, and genital areas, which are more susceptible to topical corticosteroid side effects. The efficacy of topical calcineurin inhibitors has been demonstrated for flexural psoriasis, seborrhoeic, contact and hand eczema. Preliminary data also support the efficacy of topical calcineurin inhibitors in lichen planus, facial lupus erythematosus, autoimmune bullous dermatosis, and vitiligo. In these latter indications, controlled studies are needed to better understand the efficacy and safety of topical calcineurin inhibitors and their role in disease management.

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“…Aseptic osteonecrosis of the femoral heads has previously been reported after other local corticosteroid administrations (e.g. intra-articular [1] or rectal) but are exceptional after application of cutaneous corticosteroids as only 1 case was found in the literature [6]. The total cumulative dose administered to our patient was hard to estimate precisely.…”

mentioning

confidence: 70%

Bilateral Femoral Avascular Necrosis in a Man with Psoriasis: Responsibility of Topical Corticosteroids and Role of Cyclosporine

Reichert-Pénétrat

Tréchot²,

Barbaud

et al. 2001

Dermatology

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Cataracts, glaucoma, and femoral avascular necrosis caused by topical corticosteroid ointment

Cited by 46 publications

References 3 publications

Osteonecrosis of the femoral head and glaucoma caused by topical corticosteroid application

Osteonecrosis of the femoral head and glaucoma caused by topical corticosteroid application

Potential New Indications of Topical Calcineurin Inhibitors

Bilateral Femoral Avascular Necrosis in a Man with Psoriasis: Responsibility of Topical Corticosteroids and Role of Cyclosporine

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