Cataracts in neutrophil donors stimulated with adrenal corticosteroids

Ghodsi, Zuleika; Strauss, Ronald G.

doi:10.1046/j.1537-2995.2001.41121464.x

Cited by 47 publications

(51 citation statements)

References 24 publications

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“…Besides the unknown effects of long-term recurrent administration of G-CSF, also the possible side effects of repetitive application of corticosteroids become an issue of concern. The higher risk of the development of posterior subcapsular cataract (PSC) in granulocyte donors was initially reported by Ghodsi and Strauss [33]. Two other studies [34,35] published more recently could not confirm a significant higher incidence of PSC in granulocyte donors compared with platelet donors.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Side Effects of Granulocyte Collection in Healthy Donors

Brockmann

Kramer

Bornhäuser

et al. 2013

Transfus Med Hemother

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Background: We report on the efficacy and side effects of granulocyte collection, which is comparatively infrequently performed in Germany. Methods: Data from 378 healthy donors who underwent 914 granulocyte collections between 1999 and 2007 were retrospectively analyzed. Donors received G-CSF (lenograstim) at a median dose of 5.58 (3.25-7.36) µg/kg body weight with (n = 243) or without (n = 57) 4 mg dexamethasone. Side effects were recorded by donor monitoring and interview (questionnaire). Results: The median granulocyte yield in apheresis products was 8.47 × 10¹⁰ (3.07-14.92 × 10¹⁰). Granulocyte yields correlated significantly with gender, baseline WBC, PMN and PLT counts, and nicotine consumption. Dexamethasone and lenograstim administration was more effective than lenograstim administration alone (p < 0.001). Side effects of granulocyte mobilization were generally mild: bone pain in 31.4%, headache in 19.6%, and fatigue in 15.7% of donors. During follow-up (4 weeks), pruritus and/or exanthema were reported in 17.6% of donors. Conclusions: Granulocyte mobilization with lenograstim with or without dexamethasone was a safe and effective regimen for granulocyte mobilization. Side effects were tolerable and milder than those seen in peripheral blood stem cell donors. Long-term monitoring of granulocyte donors is important to establish optimal standards for the procedure.

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Section: Discussionmentioning

confidence: 99%

Efficacy and Side Effects of Granulocyte Collection in Healthy Donors

Brockmann

Kramer

Bornhäuser

et al. 2013

Transfus Med Hemother

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“…Concerns have been raised regarding the use of repeated doses of glucocorticoids and the risk of posterior subcapsular cataracts (PSC). 42 Mild PSCs were observed in four of 11 donors who had received a mean prednisone dose of 1260 mg over 4-12 years of granulocyte donation. The risk to donors who receive a much lower dose of steroid are likely to be less, but this finding clearly requires further study.…”

Section: Adverse Effects Of Granulocyte Donationmentioning

confidence: 96%

Granulocyte transfusions in the G-CSF era. Where do we stand?

Robinson

Marks

2004

Bone Marrow Transplant

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“…Adverse effects due to long-term steroid treatment are well known and include the development of posterior subcapsular cataracts (PSC) [55]. As these complications appear with chronic use, it has been felt that the intermittent use of short-term steroid stimulation of granulocyte donors should not be associated with such complications.…”

Section: Chronic Effects Of Steroid Stimulation In Granulocyte Collecmentioning

confidence: 99%

Complications of donor apheresis

Winters

2006

J. Clin. Apheresis

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A decreasing blood donor pool in the presence of increasing blood transfusion demands has resulted in the need to maximally utilize each blood donor. This has led to a trend in the increasing use of automated blood collections. While apheresis donation shares many reactions and injuries with whole blood donation, because of the differences, unique complications also exist. Overall, evidence in the literature suggests that the frequency of reactions to apheresis donation is less than that seen in whole blood donation, though the risk of reactions requiring hospitalization is substantially greater. The most common apheresis-specific reaction is hypocalcemia due to citrate anticoagulation, which, while usually mild, has the potential for severely injuring the donor. Other reactions to apheresis donation are uncommon (e.g., hypotension) or rare (e.g., air embolism). More worrisome, and in need of additional study, are the long-term effects of apheresis donation. Recent evidence suggests that repeated apheresis platelet donations may adversely effect thrombopoiesis as well as bone mineralization. Granulocyte donation has also been implicated in unexpected long-term consequences.

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Cataracts in neutrophil donors stimulated with adrenal corticosteroids

Cited by 47 publications

References 24 publications

Efficacy and Side Effects of Granulocyte Collection in Healthy Donors

Efficacy and Side Effects of Granulocyte Collection in Healthy Donors

Granulocyte transfusions in the G-CSF era. Where do we stand?

Complications of donor apheresis

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