Catastrophic presentation of a patient with combined NMOSD and thrombotic thrombocytopenic purpura/hemolytic uremic syndrome: a case report

Okhovat, Ali Asghar; Ansari, Behnaz; Rezaali, Saeed; Altıntaş, Ayşe; Moghadasi, Abdorreza Naser

doi:10.1007/s13760-016-0710-6

Cited by 2 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TTP with spinal cord injury TTP with spinal cord injury is rarely reported. Okhovat et al reported [14] a case of neuromyelitis optica spectrum disease (NMOSD) with TTP in 2017. The patient had hemolytic uremic syndrome; however, since ADAMTS13 of this patient was not measured, it was impossible to determine whether TTP was primary or acquired.…”

Section: Ttp Complicated With Cerebrovascular Diseasementioning

confidence: 99%

Thrombotic thrombocytopenic purpura with neurological impairment: A Review

Zhu

Liu

2022

Medicine

View full text Add to dashboard Cite

The last 2 decades have witnessed considerable advances in our understanding of thrombotic thrombocytopenic purpura (TTP). However, there is still some ambiguity regarding the precise nature of this disease, especially with respect to nervous system involvement and the correct nomenclature. This article seeks to summarize the clinical manifestations of TTP and the associated diseases. We describe TTP complicated with cerebrovascular disease, spinal cord injury, posterior reversible encephalopathy syndrome (PRES), anxious-depressive symptoms, and cognitive decline. TTP with spinal cord injury is rarely reported. For better clarity, we discuss the case of a 57-year-old woman who was diagnosed with neuromyelitis optica spectrum disease (NMOSD) with atypical TTP. The concurrent occurrence of NMOSD and TTP in this patient is consistent with the characteristics of acquired autoimmunity. We highlight the importance of early recognition of TTP in patients with atypical presentation who may not have the expected clinical or laboratory findings. This is particularly important in TTP patients with other concomitant autoimmune diseases or age-related comorbid conditions.

show abstract

Section: Ttp Complicated With Cerebrovascular Diseasementioning

confidence: 99%

Thrombotic thrombocytopenic purpura with neurological impairment: A Review

Zhu

Liu

2022

Medicine

View full text Add to dashboard Cite

show abstract

“…One recently reported TTP/HUS case involved a patient who underwent simultaneous pancreas/kidney (SPK) transplant followed by pancreas rejection and clopidogrel treatment. One combined TTP/HUS case had been reported in neuromyelitis optica [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Post-Transfusion Simultaneous Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndrome: A Rare Occurrence

Patel¹,

Pawar²,

Agrawal³

et al. 2022

Cureus

View full text Add to dashboard Cite

Endothelial cell injury, intravascular platelet-fibrin thrombi, and vascular damage are found in hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). The two disorders frequently manifest independently and are the important causes of acute renal damage. Acute kidney injury developed in our patient after blood transfusion and later on, the patient developed neurological complications. The patient was managed symptomatically and conservatively. Plasmapheresis and corticosteroid administration showed improved results.

show abstract

Catastrophic presentation of a patient with combined NMOSD and thrombotic thrombocytopenic purpura/hemolytic uremic syndrome: a case report

Cited by 2 publications

References 5 publications

Thrombotic thrombocytopenic purpura with neurological impairment: A Review

Thrombotic thrombocytopenic purpura with neurological impairment: A Review

Post-Transfusion Simultaneous Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndrome: A Rare Occurrence

Contact Info

Product

Resources

About