The catastrophic August 2014 Mount Polley tailings spill, the second largest ever documented, sent ~18 Mm3 of waste plunging to the bottom of the >100 m deep West Basin of Quesnel Lake, British Columbia, a critical West Coast salmon habitat. To understand the impact of the spill on the lake, including the fate of suspended solids, we examine changes in physical water properties over 11 years (2006–2017) using water column profiles, moored timeseries, and satellite imagery. Contaminated waters were initially largely confined to the hypolimnion; however, during autumn 2014 turnover, turbid waters were mixed to the surface, resulting in the clear blue lake turning bright green. Twelve months after the spill, the lake's temperature, conductivity, and turbidity temporarily returned to pre‐spill conditions; however, initiation of mine effluent discharge in late 2015 was associated with a subsequent 15 μS cm−1 conductivity increase above historic values. Importantly, a post‐spill 1–2.5 formazin turbidity unit hypolimnetic turbidity increase was observed during spring and fall turnovers of 2015–2017, which appeared to be due to resuspension of a thin layer of unconsolidated spill‐related material from the lake bed driven by large internal seiche motions. This process implies spill contaminants may be seasonally mobilized into the water column, with potentially detrimental impacts on aquatic ecology. Our findings underscore that basin‐scale physical processes, including seasonal turnover and internal seiches, must be accounted for, even in deep lakes, to understand the long‐term impact of the ever increasing number of tailings spills into aquatic ecosystems.