Catastrophizing Interferes with Cognitive Modulation of Pain in Women with Fibromyalgia

Ellingson, Laura D.; Stegner, Aaron J.; Schwabacher, Isaac J.; Lindheimer, Jacob B.; Cook, Dane B.

doi:10.1093/pm/pny008

Cited by 61 publications

(53 citation statements)

References 62 publications

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“…Chronic pain often coexists with anxiety, depression, and pain catastrophizing [38,70,71]. Their concurrent associations as well as the predictive value of pain catastrophizing on poor outcomes for patients with chronic pain have been demonstrated in previous studies [14,[19][20][21]23]. Changes in levels of pain catastrophizing by reducing emotional distress and maladaptive behaviours can result in better pain-related outcomes [72].…”

Section: Discussionmentioning

confidence: 92%

“…In this context, one's psychological state is an important determinant of pain experiences as well as mental health [10][11][12]. Brain images indicate that cognitive and emotional modulations of pain are associated with alterations in specific brain regions [13,14]. Clinically, psychological factors such as anxiety, catastrophizing, and depressive symptoms seem to be important features of patients with chronic pain [11,15].…”

Section: Introductionmentioning

confidence: 99%

“…The fear-avoidance model illustrated the transition from a common pain episode toward persistent pain and disability via pain catastrophizing [18]. In brief, pain catastrophizing is associated with pain severity, disability, and poor outcomes for patients with chronic pain [14,[19][20][21]. Evidence suggests that pain catastrophizing in older adults is associated with sedentary behaviour which in in turn, contributed to greater pain catastrophizing [22].…”

Section: Introductionmentioning

confidence: 99%

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Pain Catastrophizing in Older Adults with Chronic Pain: The Mediator Effect of Mood Using a Path Analysis Approach

Dong

Gerdle

Bernfort

et al. 2020

JCM

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Cognitive models of pain propose that catastrophic thinking is negatively associated with chronic pain. However, pain catastrophizing is a complex phenomenon requiring a multivariate examination. This study estimates the effects of mood variables (anxiety and depression) on pain catastrophizing in older adults with chronic pain. A postal survey addressing pain aspects was sent to 6611 people ≥ 65 years old living in south-eastern Sweden. Pain catastrophizing was measured using the pain catastrophizing scale. Anxiety and depression were assessed using two subscales of the general well-being schedule. Data were analysed using a path analysis approach. A total of 2790 respondents (76.2 ± 7.4 years old) reported chronic pain (≥three months). The mediation model accounted for 16.3% of anxiety, 17.1% of depression, and 30.9% of pain catastrophizing variances. Pain intensity, insomnia, number of comorbidities, and lifestyle factors (smoking, alcohol consumption, and weight) significantly affected both pain catastrophizing and mood. Anxiety (standardized path coefficient (bstd) = 0.324, p < 0.001) in comparison to depression (bstd = 0.125, p < 0.001) had a greater effect on pain catastrophizing. Mood mediated the relationship between pain catastrophizing and pain-related factors accounting for lifestyle and sociodemographic factors.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pain Catastrophizing in Older Adults with Chronic Pain: The Mediator Effect of Mood Using a Path Analysis Approach

Dong

Gerdle

Bernfort

et al. 2020

JCM

View full text Add to dashboard Cite

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“…PCS correlate also with anxiety and depression [28]. In an elegant study that used functional magnetic resonance imaging, Ellingson and coworkers demonstrated that the tendency to catastrophism interferes with neural processes involved in pain modulation in FMS [29]. Acupuncture can, therefore, have powerful central effects in pain modulation, potentially also affecting cognitive aspects.…”

Section: Discussionmentioning

confidence: 99%

Acupuncture for Fibromyalgia: An Open‐Label Pragmatic Study on Effects on Disease Severity, Neuropathic Pain Features, and Pain Catastrophizing

Carlo

Beci

Salaffi

2020

Evidence-Based Complementary and Alternative Medicine

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The treatment of fibromyalgia syndrome (FMS) is still far from being optimally coded, and pharmacological strategies are often unsatisfactory. Acupuncture plays a role among nonpharmacological intervention approaches; however, there is still no clarity as to when to integrate it into therapy. The objective of this study is to explore the role of acupuncture, in terms of efficacy on main disease severity measures and pain features, in patients with nonresponsive disease, defining nonresponsive FMS characterized by a revised Fibromyalgia Impact Questionnaire (FIQ-R) ≥39 and a Patient Health Questionnaire 15-item (PHQ15) ≥5 despite optimal drug therapy. Patients were treated with weekly sessions, for a total of eight acupuncture sessions. At the baseline and at the end of the treatment cycle, a comprehensive clinical evaluation was carried out to evaluate improvements in terms of disease severity and impact on neuropathic pain features (measured with the painDETECT questionnaire (PDQ)) and pain catastrophizing (measured with the Pain Catastrophizing Scale (PCS)). At the end of the eight-week treatment, patients experienced a significant improvement in all evaluated parameters (for FIQ-R, PDQ, and PHQ15 p<0.0001, for PCS p=0.001). Of particular note is the effectiveness on manifestations that are difficult to treat such as neuropathic pain features and on negative psychological perceptions such as pain catastrophizing. It can be stated that acupuncture can be proposed also in phases of high severity of disease. Intervention with multimodal strategies, including acupuncture, could be of great benefit to patients.

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“…All types of pain are accompanied by changes in mood, attention, and motivation that exacerbate the sensory disturbance (60,61). The extent to which the sensory and affective components of pain are mechanistically linked remains to be fully determined.…”

Section: Dysfunctional Painmentioning

confidence: 99%

Capturing Novel Non-opioid Pain Targets

Woolf

2020

Biological Psychiatry

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The relatively high efficacy of opioids, which have associated risks of addiction, tolerance, and dependence, for the management of acute and terminal pain has been a major driver of the opioid crisis, together with the availability, overprescription, and diversion of these drugs. Eliminating opioids without an effective replacement is, however, no solution, as it substitutes one major problem with another. To deal successfully with the opioid crisis, we need to discover novel analgesics whose mechanisms do not involve the mu opioid receptor but that have high analgesic potency and low risk of adverse effects, particularly no abuse liability. The question is how to achieve this. There are several necessary elements; first, we need to understand the nature of pain and the mechanisms responsible for it, and second, we need to adopt novel and unbiased approaches to the identification and validation of pain targets.

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Catastrophizing Interferes with Cognitive Modulation of Pain in Women with Fibromyalgia

Cited by 61 publications

References 62 publications

Pain Catastrophizing in Older Adults with Chronic Pain: The Mediator Effect of Mood Using a Path Analysis Approach

Pain Catastrophizing in Older Adults with Chronic Pain: The Mediator Effect of Mood Using a Path Analysis Approach

Acupuncture for Fibromyalgia: An Open‐Label Pragmatic Study on Effects on Disease Severity, Neuropathic Pain Features, and Pain Catastrophizing

Capturing Novel Non-opioid Pain Targets

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