Catatonia Associated With Systemic Lupus Erythematosus (SLE): A Report of Two Cases and a Review of the Literature

Boeke, Annabel; Pullen, Bianca; Coppes, L; Medina, Michel; Cooper, Joseph J.

doi:10.1016/j.psym.2018.06.007

Cited by 43 publications

(17 citation statements)

References 40 publications

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“…It can be a manifestation of neuropsychiatric lupus, particularly with laboratory values that indicate acute lupus flares at the time of presentation. In most of the cases, catatonia was improved with immunosuppressive therapy [100] and worsened with antipsychotic medications, including precipitating neuroleptic malignant syndrome; hence, recognition of catatonia is important [101]. Benzodiazepines were the first-line treatment for catatonia, and ECT was used for catatonia refractory to benzodiazepines [102].…”

Section: ) Catatoniamentioning

confidence: 99%

Psychiatric Symptoms in Systemic Lupus Erythematosus: Diagnosis and Treatment

2019

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According to the American College of Rheumatology classification, lupus erythematosus has five psychiatric manifestations, including cognitive dysfunction, mood disorder, anxiety disorder, psychosis, and acute confusional state, which are frequently accompanied by other symptoms. Cognitive dysfunction is the most common psychiatric manifestation in lupus patients with a prevalence rate ranging from 20% to 80%. The expression of psychiatric manifestations has been considered to be associated with disease activity, side effects of medications, and/or psychosocial stresses from the chronicity of lupus, but this has not been fully understood. Appropriate management of psychiatric symptoms is essential as it affects treatment adherence and quality of life. This review aimed to facilitate understanding of psychiatric manifestations of lupus through literature review on the prevalence, clinical features, diagnosis, and treatments of each psychiatric symptom.

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Section: ) Catatoniamentioning

confidence: 99%

Psychiatric Symptoms in Systemic Lupus Erythematosus: Diagnosis and Treatment

2019

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“…Neuropsychiatric SLE includes a constellation of symptomsboth neurological and psychiatric secondary to central nervous system involvement [11]. Catatonia as a presenting feature of NPSLE is uncommon.…”

Section: Discussionmentioning

confidence: 99%

Atypical Initial Presentations of SLE – Our Experience From A Tertiary Centre In Eastern India

Kumar¹

2021

ARAR

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“…72 Response rates of ECT in catatonia are reported at 80-100%, making it the definitive treatment when benzodiazepines have failed to alleviate the catatonic state. 81,85 ECT has also been shown to be more effective when combined with ongoing benzodiazepine administration, so combination therapy is generally recommended. 53 ECT is effective in catatonia secondary to medical conditions such as myocardial infarction, lupus, encephalomyelitis, multiple sclerosis, and other pathologies.…”

Section: Electroconvulsive Therapymentioning

confidence: 99%

Malignant Catatonia: A Review for the Intensivist

Connell

Oldham

Pandharipande

et al. 2022

J Intensive Care Med

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Catatonia is a clinical syndrome characterized by psychomotor, neurological and behavioral changes. The clinical picture of catatonia ranges from akinetic stupor to severe motoric excitement. Catatonia can occur in the setting of a primary psychiatric condition such as bipolar disorder or secondary to a general medical illness like autoimmune encephalitis. Importantly, it can co-occur with delirium or coma. Malignant catatonia describes catatonia that presents with clinically significant autonomic abnormalities including change in temperature, blood pressure, heart rate, and respiratory rate. It is a life-threatening form of acute brain dysfunction that has several motoric manifestations and occurs secondary to a primary psychiatric condition or a medical cause. Many of the established predisposing and precipitating factors for catatonia such as exposure to neuroleptic medications or withdrawal states are common in the setting of critical illness. Catatonia typically improves with benzodiazepines and treatment of its underlying psychiatric or medical conditions, with electroconvulsive therapy reserved for catatonia refractory to benzodiazepines or for malignant catatonia. However, some forms of catatonia, such as catatonia secondary to a general medical condition or catatonia comorbid with delirium, may be less responsive to traditional treatments. Prompt recognition and treatment of catatonia are crucial because malignant catatonia may be fatal without treatment. Given the high morbidity and mortality associated with malignant catatonia, intensivists should familiarize themselves with this important and under-recognized condition.

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Catatonia Associated With Systemic Lupus Erythematosus (SLE): A Report of Two Cases and a Review of the Literature

Cited by 43 publications

References 40 publications

Psychiatric Symptoms in Systemic Lupus Erythematosus: Diagnosis and Treatment

Psychiatric Symptoms in Systemic Lupus Erythematosus: Diagnosis and Treatment

Atypical Initial Presentations of SLE – Our Experience From A Tertiary Centre In Eastern India

Malignant Catatonia: A Review for the Intensivist

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