Catatonic Reaction to Accidental Haloperidol Overdose: An Unrecognized Drug Abuse Risk

Hoffman, Amy S.; Schwartz, Harold I.; Novick, Rona M.

doi:10.1097/00005053-198607000-00007

Cited by 8 publications

(5 citation statements)

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“…XX в. [64,65], в последующем получили подтверждение в ряде более современных исследований, включая случаи злокачественного нейролептического синдрома, который, по мнению ряда клиницистов, может рассматриваться как ятрогенно провоцированный эквивалент злокачественной кататонии [66][67][68][69].…”

Section: нейролептические препараты (антипсихотики)unclassified

“…В пользу обоснованности такого подхода свидетельствует ряд клинических фактов. Во-первых, потенциальные риски ятрогенной кататонии соотносятся преимущественно с антипсихотиками (нейролептиками) первого поколения (АПП) [66,67]. Во-вторых, применение антипсихотиков второго (АВП) и третьего поколения (АТП) сопряжено со значительно меньшей вероятностью развития ЗНС (для некоторых из них, например луразидона, карипразина, таких случаев пока вообще не зарегистрировано).…”

Section: нейролептические препараты (антипсихотики)unclassified

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Therapy of Catatonia in Schizophrenia and Schizophrenia Spectrum Disorders

Ivanov

Borisova

et al. 2022

Psychiatry

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Background: the study of catatonia’s treatment methods is one of the most important researchers’ tasks, nevertheless the common therapeutic strategies of cupping the catatonic phenomena haven’t been created yet. The aim: review to therapeutic interventions for catatonic disorders in schizophrenia.Materials and methods: according to the keywords “catatonia treatment”, “catatonia therapy”, publications found in the Scopus, PubMed, Cochrane Library, eLibrary databases were selected and analyzed.Results: historical background, illustrating the development of catatonia treatment methods, is given; the results of the last decades scientific studies of catatonia’s treatment and preliminary results of own study, devoted to the effectiveness of diazepam and cariprazine in relieving catatonia manifestations are presented. Based on the studies’ results, presented in the review, it can be concluded that the most common modern method of treating catatonic disorders is the use of benzodiazepines, however, in some cases, the use of antipsychotics is also advisable. Electroconvulsive therapy (ECT) remains an important treatment for catatonic phenomena. There are also isolated clinical cases of successful testing of both: other pharmacological groups (antidepressants, dopaminergic and anticholinergic drugs, normothymic drugs, etc.) and non-drug interventions (transcranial magnetic stimulation — TMS) presented in modern research data.Conclusion: the effectiveness of benzodiazepines in catatonia, associated with schizophrenia and schizophrenia spectrum disorders (SSD), remains controversial according to modern authors’ opinion. In turn, among antipsychotics, antipsychotics of the second and third generation seem to be safe for the treatment of psychomotor symptoms. In accordance with the results of our own study, catatonia in the structure of schizophrenia and SSD is heterogeneous and, depending on the psychopathological structure of catatonic disorders, a different reaction of psychomotor symptoms to therapeutic intervention was observed.

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Section: нейролептические препараты (антипсихотики)unclassified

Therapy of Catatonia in Schizophrenia and Schizophrenia Spectrum Disorders

Ivanov

Borisova

et al. 2022

Psychiatry

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“…Following the administration of loxapine, eight individuals had symptoms of catatonia, according to a 1977 report ( 8 ). Another case study from 1986 documented a 19-year-old male who developed parkinsonian and catatonic symptoms after accidentally ingesting haloperidol 30 mg by mouth ( 9 ). A young female had autonomic disturbances and catatonic symptoms after administration of haloperidol, biperiden, thioridazine, and haloperidol decanoate in a case report ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Case report on antipsychotic induced catatonia in an incarcerated patient

Nguyen,

Cannell,

Rollakanti

et al. 2023

Front. Psychiatry

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Antipsychotic-induced catatonia is an iatrogenic and debilitating adverse reaction, but there is a dearth of recent documented cases. This report describes a 35-year-old incarcerated Korean-American male with a history of unspecified psychosis who presented for antipsychotic induced catatonia after administration of haloperidol decanoate intramuscular (200 mg across the span of 1 week). Neurologic workup was performed including MRI, lumbar puncture, and electroencephalography. Despite an approximate month long hospitalization, benzodiazepine challenge, benztropine trial, and amantadine adjunct, our patient continued to experience bradykinesia, waxy flexibility, and mask-like facies, and was minimally verbally responsive. Several challenges in the treatment of incarcerated individuals at the hospital are highlighted in this case report, including adverse reaction to medication, difficulty of care coordination, and limited access to health records among providers.

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“…Few anecdotal reports have been published on the deliberate misuse of haloperidol tablets. One article described an individual who developed catatonia after using haloperidol tablets purchased from the streets to “get high” [ 4 ]. Another paper depicted a patient who used haloperidol tablets concurrently with street-made “designer drugs” to counteract their undesirable psychotropic actions and to potentially enhance euphoria; this patient later presented to an emergency department (ED) with torticollis [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Acute Extrapyramidal Side Effects from Smoked Haloperidol

Pham

Lee

Miller

2021

Case Reports in Psychiatry

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Introduction. Haloperidol is a dopamine receptor antagonist used to treat patients with psychotic disorders. Especially at high doses, haloperidol carries a higher risk of extrapyramidal symptoms (EPS) compared to second-generation antipsychotics. Few cases of haloperidol misuse are found in the medical literature. Case Presentation. We describe a patient with schizophrenia who smoked marijuana mixed with crushed haloperidol tablets. After the smoking of cannabis and haloperidol, the patient presented to the emergency department (ED) with suicidal ideation, psychosis, and acute dystonia. With the administration of intramuscular diphenhydramine at the ED, the dystonia resolved in less than an hour. To our knowledge, this is the first report on haloperidol misuse by smoking. Conclusion. Clinicians should be aware that patients might misuse prescribed antipsychotics via unconventional routes, potentially combined with other substances.

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Catatonic Reaction to Accidental Haloperidol Overdose: An Unrecognized Drug Abuse Risk

Cited by 8 publications

References 0 publications

Therapy of Catatonia in Schizophrenia and Schizophrenia Spectrum Disorders

Therapy of Catatonia in Schizophrenia and Schizophrenia Spectrum Disorders

Case report on antipsychotic induced catatonia in an incarcerated patient

Acute Extrapyramidal Side Effects from Smoked Haloperidol

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