Catch-up in height and skeletal maturity in children on long-term treatment for hypothyroidism

Harnack, G.-A. von; Tanner, J. M.; Whitehouse, R. H.; Rodríguez, Carlos Aníbal

doi:10.1007/bf00491961

Cited by 15 publications

(6 citation statements)

References 7 publications

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“…This is not very much compared to other patients with GHD [4,6,16,19,23]. However, the difference between the patient's height and the mean height for girls with gonadal dysgenesis (45 XO) was less at the end of hGH therapy than prior to it, which demonstrates a catch-up growth [12]. The growth rate achieved in this patient is comparable to that obtained in other patients with GHD with no chromosomal defects.…”

Section: Discussionsupporting

confidence: 79%

Growth hormone deficiency and growth hormone therapy in Ullrich-Turner-Syndrome

Butenandt

1980

Klin Wochenschr

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In a girl with Ullrich-Turner-Syndrome (gonadal dysgenesis 45, XO) and growth hormone deficiency, 10 U of human growth hormone/m2 body surface area/week increased the growth rate from 2.0 to 4.1 cm/year. Doses of up to 36 U/m2/week did not improve the growth rate in 4 girls with Ullrich-Turner-Syndrome who had normal plasma growth hormone concentration and increation. We conclude that growth hormone therapy is unsuccessful in dwarfism in Ullrich-Turner-Syndrome and should be reserved for patients with proven growth hormone deficiency.

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Section: Discussionsupporting

confidence: 79%

Growth hormone deficiency and growth hormone therapy in Ullrich-Turner-Syndrome

Butenandt

1980

Klin Wochenschr

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“…At delivery children with congenital hypothyroidism have a length similar to that of healthy children, but without re placement therapy with L-thyroxine (L-T4) their growth rate diminishes shortly afterwards [2,4,7]. A continuing decrease or even complete arrest of statural growth is ob served if congenital or acquired juvenile hypothyroidism remains untreated.…”

Section: Introductionmentioning

confidence: 99%

“…A continuing decrease or even complete arrest of statural growth is ob served if congenital or acquired juvenile hypothyroidism remains untreated. It has been suggested that adequate treatment of hypothyroidism leads to complete catch-up growth and a normal adult stature [4,12,16]. It is now clear that short stature can indeed be prevented if L-T4 substitution is started at an early age [1,3], but if hy pothyroidism remains untreated for a longer period a per manent height loss cannot always be avoided [2,11,13].…”

Section: Introductionmentioning

confidence: 99%

Catch-up growth after prolonged hypothyroidism

et al. 1996

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“…After the onset of T4 replacement therapy, growth and skeletal abnormalities usually resolve and a period of catch-up growth ensues. In the past, it has been suggested that catch-up growth in children treated for congenital or juvenile hypothyroidism is complete, and that such children usually reach their expected adult height [17][18][19][20][21], but this is not supported by recent reports showing a failure of catch-up growth in children in whom treatment has been initiated after a long period of untreated hypothyroidism [22][23][24].…”

Section: Introductionmentioning

confidence: 99%