2006
DOI: 10.1016/j.lfs.2006.02.028
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(+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation

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Cited by 42 publications
(21 citation statements)
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References 38 publications
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“…These data demonstrate that the MTOR pathway may not be involved in the ER response to UVB radiation. Wu et al reported that JNK activation was required for apoptotic induction, and (+)-Catechin prevented UVB triggered apoptosis in keratinocytes through inhibiting JNK phosphorylation [100]. Our data verified that JNK activation is a key cellular event in cell photodamage because it has been observed in cells challenged with either UVB or UVA.…”
Section: Discussionsupporting
confidence: 86%
“…These data demonstrate that the MTOR pathway may not be involved in the ER response to UVB radiation. Wu et al reported that JNK activation was required for apoptotic induction, and (+)-Catechin prevented UVB triggered apoptosis in keratinocytes through inhibiting JNK phosphorylation [100]. Our data verified that JNK activation is a key cellular event in cell photodamage because it has been observed in cells challenged with either UVB or UVA.…”
Section: Discussionsupporting
confidence: 86%
“…In this study, fucoidan enhanced the expression of p-ERK and p-JNK in non-UVBinduced cells. Wu et al 24) also observed that treatments with catechin in non-UVB cell had a slightly activated the ERK and JNK phosphorylation. Shin et al 25) reported that pretreatment with DHEA inhibited also c-fos and c-jun (downstream of ERK and JNK) expression.…”
Section: Discussionmentioning
confidence: 92%
“…Catechin prevented UVB-induced human keratinocyte death via inhibition of JNK phosphorylation [48], as well as mitogen-activated protein kinase (MAPK) pathway and NF-kB pathway [49]. Treatment of the normal human epidermal keratinocytes (NHEK) with EGCG (10-40 μM) for 24 h resulted in a significant inhibition of UVB (40 mJ/cm 2 )-mediated degradation and phosphorylation of I k Bα and activation of MAPK and IKKα, in a dose-dependent manner.…”
Section: Regulation Of Gene Expressionmentioning
confidence: 99%