Catechol-O-Methyltransferase (COMT) Gene Polymorphisms as Risk Factor in Temporomandibular Disorders Patients From Southern Italy

Michelotti, Ambrosina; Liguori, Rosario; Toriello, Mario; D’Antò, Vincenzo; Vitale, Dino Franco; Castaldo, Giuseppe; Sacchetti, Lucia

doi:10.1097/ajp.0b013e318287a358

Cited by 31 publications

(40 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This polymorphism now joins four other described polymorphisms that have already been associated with this condition. 40,41 Although COMT has been previously studied and associated with TMD in adults, 22,23 to the best of our knowledge, our study is the first investigating these genes in adolescents. This is significant because the adolescent population has had less time for gene-environment interactions, particularly psychological stress, to affect them than adults.…”

Section: Discussionmentioning

confidence: 91%

“…Although 5HTT and COMT have been previously studied and associated with TMD in adults, to the best of our knowledge, this is the first study of these genes in adolescents. We also observed that individuals with TMD signs and symptoms had a higher anxiety level, and polymorphisms in COMT and 5HTT contributed for both conditions; however, we did not investigate aetiologic factors that could be triggering anxiety in the adolescents.…”

Section: Discussionmentioning

confidence: 97%

“…In this scenario, two specific genes are candidates to be studied once they have been suggested to contribute to anxiety disorders, stress, 17,18 painful conditions [19][20][21][22][23] and TMD 12,24 : serotonin transporter gene (5HTT) and catechol-O-methyltransferase (COMT). Both genes encode proteins that are present in the synaptic cleft and are involved in the reuptake of neurotransmitters.…”

Section: Backg Rou N Dmentioning

confidence: 99%

“…The influence of psychological factors on TMD development is unknown, but there is a possibility that genetic polymorphisms previously associated with stress and depression could be involved as mediating factors in the relationship between anxiety and TMD. In this scenario, two specific genes are candidates to be studied once they have been suggested to contribute to anxiety disorders, stress, painful conditions and TMD: serotonin transporter gene ( 5HTT ) and catechol‐O‐methyltransferase ( COMT ). Both genes encode proteins that are present in the synaptic cleft and are involved in the reuptake of neurotransmitters.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The association of genetic polymorphisms in serotonin transporter and catechol‐O‐methyltransferase on temporomandibular disorders and anxiety in adolescents

Brancher

Spada

Meger

et al. 2019

J of Oral Rehabilitation

View full text Add to dashboard Cite

Summary Background Temporomandibular disorder (TMD) is a multifactorial condition involving environmental, psychological and genetic factors. Objective The aim of this case‐control study was to evaluate the influence of genetic polymorphisms in 5HTT and COMT on TMD and anxiety in adolescents. Methods TMD was diagnosed and classified according to the RDC/TMD criteria. For case group, the following TMD categories were used: myofascial pain, disc displacement, arthralgia and painful TMD (myofascial and arthralgia). Anxiety levels were assessed according to the State‐Trait Anxiety Inventory. Genomic DNA was extracted, and genetic polymorphisms were genotyped by TaqMan chemistry and endpoint analysis. Logistic multivariate regression was used to analyse the associations between TMD types and genotypes, anxiety level and genotypes, using an adjusted odds ratio (ORa; CI 95%) that considered the gender. Results In 5HTT, the rs1042173 was associated with painful TMD (arthralgia and myofascial pain) (ORc = 1.97; CI 95%: 1.02‐3.77; P = 0.04). Polymorphisms in COMT rs4818 were significantly associated with myofascial pain (ORc = 2.15; CI 95%: 1.08‐4.29; P = 0.02) and were borderline for painful TMD (ORc = 1.85; CI 95%: 0.97‐3.51; P = 0.06) and disc displacement (ORc = 2.42; CI 95%: 1.00‐5.87; P = 0.05). The rs6269 was borderline for myofascial pain (ORc = 1.82; CI 95%: 0.92‐3.59; P = 0.08) and disc displacement (ORc = 2.38; CI 95% 0.95‐5.97; P = 0.06) and also was associated with anxiety (ORa = 2.34; CI 95% 1.04‐5.25; P = 0.03). Conclusion Polymorphisms in 5HTT and COMT are associated with TMD in adolescents. Moreover, polymorphism in COMT is associated with anxiety in adolescents.

show abstract

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 97%

Section: Backg Rou N Dmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The association of genetic polymorphisms in serotonin transporter and catechol‐O‐methyltransferase on temporomandibular disorders and anxiety in adolescents

Brancher

Spada

Meger

et al. 2019

J of Oral Rehabilitation

View full text Add to dashboard Cite

show abstract

“…Temporomandibular joint osteoarthritis (TMJOA) is one of the most common forms of temporomandibular disorders (TMD), which primarily afflicts women aged 20–40 years . Several studies also suggest that genetic factors, such as oestrogen receptor and matrix metalloproteinase gene polymorphisms may be associated with TMJOA . Genetic polymorphisms may contribute to TMJOA by lowering the threshold for tissue damage from adverse loading or acute joint injury .…”

Section: Introductionmentioning

confidence: 99%

Association of GDF5, SMAD3 and RUNX2 polymorphisms with temporomandibular joint osteoarthritis in female Han Chinese

Xiao

Meng

Gan

et al. 2015

J of Oral Rehabilitation

View full text Add to dashboard Cite

Temporomandibular joint osteoarthritis (TMJOA) is a complex disease and has a strong genetic component in its pathogenesis. Experimental evidence suggests the involvement of biological pathway in the disease. This case-control study was designed to investigate whether five common single nucleotide polymorphisms (SNPs) in GDF5, SMAD3, RUNX2, TGFβ1 and CHST11, respectively, are associated with TMJOA in female Han Chinese patients. A total of 240 participants were evaluated comprising 114 female patients diagnosed with TMJOA based on Research Diagnostic Criteria for Temporomandibular Disorders and 126 healthy female controls. The SNPs of the five genes in the genomic DNA were examined by sequencing, and their allelic, genotypic and carriage rate frequency distributions, as well as the triple combination of the risk genotypes, were analysed using the logistic regression model. The SNP in GDF5 or SMAD3 showed significant association with TMJOA, a relatively weak association was observed in RUNX2. In the triple combinational analysis, the risk of TMJOA grew 5·09 times in the patients with five or six risk alleles (P < 0·01). This is the first study to evaluate the association of GDF5, SMAD3, RUNX2, TGFβ1 and CHST11 with TMJOA in female Han Chinese. Our study suggests that the SNPs of genes related to TGFβ family might contribute to the risk of TMJOA.

show abstract

Genetic variation in catechol‐O‐methyltransferase is associated with individual differences in conditioned pain modulation in healthy subjects

Korczeniewska

Kuo

Huang

et al. 2021

The Journal of Gene Medicine

View full text Add to dashboard Cite

Background Genetic variation in the catechol‐O‐methyltransferase (COMT) gene is associated with sensitivity to both acute experimental pain and chronic pain conditions. Four single nucleotide polymorphisms (SNPs) have traditionally been used to infer three common haplotypes designated as low, average and high pain sensitivity and are reported to affect both COMT enzymatic activity and pain sensitivity. One mechanism that may partly explain individual differences in sensitivity to pain is conditioned pain modulation (CPM). We hypothesized that variation in CPM may have a genetic basis. Methods We evaluated CPM in 77 healthy pain‐free Caucasian subjects by applying repeated mechanical stimuli to the dominant forearm using 26‐g von Frey filament as the test stimulus with immersion of the non‐dominant hand in hot water as the conditioning stimulus. We assayed COMT SNP genotypes by the TaqMan method using DNA extracted from saliva. Results SNP rs4680 (val158met) was not associated with individual differences in CPM. However, CPM was associated with COMT low pain sensitivity haplotypes under an additive model (p = 0.004) and the effect was independent of gender. Conclusions We show that, although four SNPs are used to infer COMT haplotypes, the low pain sensitivity haplotype is determined by SNP rs6269 (located in the 5′ regulatory region of COMT), suggesting that inherited variation in gene expression may underlie individual differences in pain modulation. Analysis of 13 global populations revealed that the COMT low pain sensitivity haplotype varies in frequency from 13% to 44% and showed that two SNPs are sufficient to distinguish all COMT haplotypes in most populations.

show abstract

Catechol-O-Methyltransferase (COMT) Gene Polymorphisms as Risk Factor in Temporomandibular Disorders Patients From Southern Italy

Abstract: Our data extend the number of SNPs present in the promoter region that could play a regulatory role in COMT gene and suggest that the genetic polymorphisms rs 165656 and rs 4646310 exert a role in TMD susceptibility.

Cited by 31 publications

References 23 publications

The association of genetic polymorphisms in serotonin transporter and catechol‐O‐methyltransferase on temporomandibular disorders and anxiety in adolescents

The association of genetic polymorphisms in serotonin transporter and catechol‐O‐methyltransferase on temporomandibular disorders and anxiety in adolescents

Association of GDF5, SMAD3 and RUNX2 polymorphisms with temporomandibular joint osteoarthritis in female Han Chinese

Genetic variation in catechol‐O‐methyltransferase is associated with individual differences in conditioned pain modulation in healthy subjects

Contact Info

Product

Resources

About