1982
DOI: 10.1016/0006-8993(82)90996-9
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Catecholamine alterations in basal ganglia after hippocampal lesions

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Cited by 73 publications
(11 citation statements)
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“…Our neurochemical results are in agreement with previous findings that HPC lesions decrease DA metabolites and NE in the NAc (Springer and Isaacson, ). Interestingly, we demonstrated that vHPC lesions attenuate HVA and HVA/DA in STs but not GTs.…”
Section: Discussionsupporting
confidence: 93%
“…Our neurochemical results are in agreement with previous findings that HPC lesions decrease DA metabolites and NE in the NAc (Springer and Isaacson, ). Interestingly, we demonstrated that vHPC lesions attenuate HVA and HVA/DA in STs but not GTs.…”
Section: Discussionsupporting
confidence: 93%
“…Second, given the observations in Glowinski's laboratory of an excitatory effect of glutamate upon dopamine release (see above), one might expect just the opposite result: a reduction in dopaminergic transmission. An effect of this kind has also been reported after hippocampal aspiration: In n. accumbens (but not in the dorsal striatum) there was a reduction in dopamine use, this effect being observed at 7 but not 28 days after the lesion (Springer & Isaacson 1982). These authors also report an up-regulation of accumbens dopamine receptor binding 28 days after hippocampectomy, whereas we observed a (nonsignificant) decrease.…”
Section: Brain Dysfunction In Schizophreniasupporting
confidence: 84%
“…These results may be particularly relevant within the context of studies aimed at developing pathophysiological models of schizophrenia; much research of this nature has focused on the effects of chronic hippocampal inactivation by excitotoxic or electrolytic lesions on indices of dopaminergic transmission. Many studies have reported that lesions of the ventral hippocampus alter behavioural, pharmacological, or neurochemical indices of dopaminergic transmission and that such alterations emerge days or weeks following lesions (Springer & Isaacson, 1982; Lipska et al ., 1992, 1995). For instance, hippocampal lesions increase exploration and investigatory stereotypes produced by injections of dopamine agonists (Reinstein et al ., 1982; Lipska & Weinberger, 1993; Mittleman et al ., 1993), augment elevations in NAS dopamine evoked by amphetamine (Wilkinson et al ., 1993), and enhance the behavioural suppressant effects of antipsychotic drugs (Lipska & Weinberger, 1993).…”
Section: Discussionmentioning
confidence: 99%