Catecholamine and Thyroid Hormone Metabolism in a Case of Anorexia Nervosa.

Satô, Tamotsu; Igarashi, Noboru; Miyagawa, Kazuhiko; Nakajima, T.; Katayama, Keita

doi:10.1507/endocrj1954.35.295

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…We did not measure catecholamines in our subjects but a previous study by Sato et al (1988) has shown that subjects with anorexia nervosa with initial emaciation have adrenergic hyperactivity, while in the stabilisation phase the adrenergic tone is reduced. A possible alternative mechanism for modulation of glucocorticoid action could be an alternative splicing of the glucocorticoid receptor: GR could act as a dominant negative inhibitor of GR action (Ray 1996).…”

Section: Discussionmentioning

confidence: 99%

Regulation of corticosteroid receptors in patients with anorexia nervosa and Cushing's syndrome

Armanini

Spinella²,

Simoncini³

et al. 1998

Journal of Endocrinology

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We have studied 16 patients with anorexia nervosa (11 with a stabilised weight loss and 5 in the weight-losing phase), 11 healthy controls, and 10 patients with Cushing's syndrome, by measuring plasma cortisol (by enzymeimmunoassay), ACTH (by RIA), corticosteroid (Type I-mineralocorticoid and Type II-glucocorticoid) receptors in mononuclear leukocytes (by radio-receptor assay), and lymphocyte subpopulations (by cytofluorimetry).In anorexic patients with a stabilised weight loss and in Cushing's syndrome the mean value of both Type I and Type II corticosteroid receptors in mononuclear leukocytes was significantly lower than in controls.

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Section: Discussionmentioning

confidence: 99%

Regulation of corticosteroid receptors in patients with anorexia nervosa and Cushing's syndrome

Armanini

Spinella²,

Simoncini³

et al. 1998

Journal of Endocrinology

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show abstract

“…In anorectic patients, responses of GH, corti¬ sol and epinephrine to hypoglycemia have been studied (Mecklenburg et al 1974;Brauman & Gré¬ goire 1975;Frankel & Jenkins 1975;Aro et al 1977;Sato et al 1988), whereas there has been no study of glucagon response to insulin-induced hypo¬ glycemia. Recently, we (Rumai et al 1988) reported that glucagon secretion was not suppressed by hyperglycemia after a glucose load in anorectic pa¬ tients.…”

mentioning

confidence: 99%

Impaired glucagon secretion to insulin-induced hypoglycemia in anorexia nervosa

Fujii

Tamai²,

Kumai³

et al. 1989

Acta Endocrinologica

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In order to clarify the role played by pancreatic \g=a\-celldysfunction in the impaired glucose recovery from hypoglycemia in patients with anorexia nervosa, the response of pancreatic \g=a\-cells to insulin-induced hypoglycemia was investigated in 16 patients with anorexia nervosa before and after treatment. The results were compared with those obtained after loading with arginine. Before treatment, despite comparable falls in plasma glucose levels, glucagon secretion was significantly reduced in the anorectic patients compared with control subjects. In addition, glucose recovery from hypoglycemia in the patients was attenuated. However, after treatment, both glucagon secretory activity and plasma glucose recovery following insulin-induced hypoglycemia were restored to normal. Plasma glucagon responses to arginine infusion were not significantly different in the untreated anorectic patients and control subjects. However, the plasma insulin response in the patients was significantly lower than in the control group. These results suggest that the impaired recovery of plasma glucose levels from insulin-induced hypoglycemia in patients with anorexia nervosa is primarily attributable to impaired pancreatic \g=a\-secretorycapability. In addition, this abnormality in pancreatic \g=a\-cellfunction is reversible with treatment leading to improved nutrition and weight gain.

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Körperliche Folgeerkrankungen von Essstörungen

Cuntz

2011

S3-Leitlinie Diagnostik Und Behandlung Der Essstörungen

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Catecholamine and Thyroid Hormone Metabolism in a Case of Anorexia Nervosa.

Abstract: Alterationsin catecholamine (CA) and thyroid hormone metabolism were examined in a 12-year

Cited by 7 publications

References 12 publications

Regulation of corticosteroid receptors in patients with anorexia nervosa and Cushing's syndrome

Regulation of corticosteroid receptors in patients with anorexia nervosa and Cushing's syndrome

Impaired glucagon secretion to insulin-induced hypoglycemia in anorexia nervosa

Körperliche Folgeerkrankungen von Essstörungen

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