Catecholamine-Containing Cells in the Nerve Plexus of the Guinea Pig Gallbladder

Cai, Wenqin; Gabella, Giorgio

doi:10.1159/000145856

Cited by 14 publications

(5 citation statements)

References 7 publications

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“…The findings of the present study are in accordance with the observations of Cai and Gabella [1984] as regards the morphology and distribution of fluorescent cells in the gall-bladder. Similar catecholamine-containing cells have been reported in paravertebral and prevertebral ganglia [reviewed in Taxi.…”

Section: Discussionsupporting

confidence: 93%

Degeneration of Adrenergic Nerves in the Gail-Bladder of Cholecystitis Patients

Qayyum

Fatani²,

Khuaiter³

et al. 1988

Cells Tissues Organs

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The adrenergic innervation of the gall-bladder of healthy persons and patients suffering from cholecystitis has been studied following fluorescence histochemical methods.The normal gall-bladder is moderately innervated by adrenergic nerve fibres. Fine nerve fibres have been observed in the lamina propria, fibromuscularis and serosa. Catecholamine-containing fluorescent cells have been observed at different sites and their possible role as chemoreceptors and their endocrine nature have been reaffirmed. Adrenergic nerve fibres show signs of degeneration in cholecystitis as is evidenced by swelling of the nerve fibres and enhanced intensity of fluorescence in fluorescent cells.

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Section: Discussionsupporting

confidence: 93%

Degeneration of Adrenergic Nerves in the Gail-Bladder of Cholecystitis Patients

Qayyum

Fatani²,

Khuaiter³

et al. 1988

Cells Tissues Organs

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“…In the gallbladder of the guinea pig, the subserosal plexus (Figs. 1 and 2) is composed of a network of small, irregular, triangular‐ or ovoid‐shaped ganglia (Sutherland, 1967; Cai and Gabella, 1983, 1984; Mawe and Gershon, 1989). Ganglia are interconnected by tracts of unmyelinated axons, which are contiguous with paravascular nerve bundles that follow the extensive vascular distribution in this layer.…”

Section: Neuroanatomy Of Gallbladder So and Bile Ductsmentioning

confidence: 99%

“…Guinea pig gallbladder ganglia also contain small catecholamine‐histofluorescent cells that are immunoreactive for tyrosine hydroxylase (TH), but not dopamine‐β‐hydroxylase (DβH). The catecholamine that they express is suggested to be dopamine, but their role has not been established (Cai and Gabella, 1983, 1984; Mawe and Gershon, 1989; Mawe et al, 1997; Mawe and Ellis, 2001). Chemical coding of nerve fibers has revealed that in the paravascular plexus, CGRP and SP colocalize with PACAP in extrinsic sensory fibers.…”

Section: Neuroanatomy Of Gallbladder So and Bile Ductsmentioning

confidence: 99%

“…The gallbladder contains abundant sympathetic postganglionic nerve fibers that arise from the celiac and superior mesenteric ganglia. Catecholamine histofluorescence and immunohistochemical detection of TH and dopamine beta hydroxylase (DβH) have been used to identify the sympathetic postganglionic nerves in the wall of the gallbladder (Cai and Gabella, 1983, 1984; Mawe and Gershon, 1989). In the guinea pig gallbladder, sympathetic postganglionic nerves course along blood vessels within the paravascular and perivascular plexuses (Fig.…”

Section: Extrinsic Innervation Of Gallbladder So and Bile Ductsmentioning

confidence: 99%

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Innervation of the extrahepatic biliary tract

2004

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The extrahepatic biliary tract is innervated by dense networks of extrinsic and intrinsic nerves that regulates smooth muscle tone and epithelial cell function of extrahepatic biliary tree. Although these ganglia are derived from the same set of precursor neural crest cells that colonize the gut, they exhibit structural, neurochemical, and physiological characteristics that are distinct from the neurons of the enteric nervous system. Gallbladder neurons are relatively inexcitable, and their output is driven by vagal inputs and modulated by hormones, peptides released from sensory fibers, and inflammatory mediators. Gallbladder neurons are cholinergic and they can express a number of other neural active compounds, including substance P, galanin, nitric oxide, and vasoactive intestinal peptide. Sphincter of Oddi (SO) ganglia, which are connected to ganglia of the duodenum, appear to be comprised of distinct populations of excitatory and inhibitory neurons, based on their expression of choline acetyltransferase and substance P or nitric oxide synthase, respectively. While SO neurons likely receive vagal input and their activity is modulated by release of neuropeptides from sensory fibers, a significant source of excitatory synaptic input to these cells arise from the duodenum. This duodenum-SO circuit is likely to play an important role in the coordination of SO tone with gallbladder motility in the process of gallbladder emptying. Now that we have gained a relatively thorough understanding of the innervation of the biliary tree under healthy conditions, the way is paved for future studies of altered neural function in biliary disease.

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“…The gallbladder contains abundant sympathetic postganglionic nerve fibres that arise from the celiac and superior mesenteric ganglia. Catecholamine histofluorescence and immunohistochemical detection of TH and dopamine beta hydroxylase have been used to identify the sympathetic postganglionic nerves in the wall of the gallbladder (Cai & Gabella, 1983;1984;Mawe & Gershon, 1989). According to Balemba et al (2004) TH positive neurons in the gallbladder were relatively small.…”

Section: Discussionmentioning

confidence: 99%

Tyrosine hydroxylase positive nerves and mast cells in the porcine gallbladder

Stefanov¹,

Vodenicharov²,

Tsandev³

et al. 2017

BJVM

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The aim of this study was to detect the localisation of tyrosine hydroxylase (TH) positive nerve fibres (THN) and distribution of tyrosine hydroxylase positive mast cells (THMC) in the wall of porcine gallbladder. THN were observed as single fibres, nerve fibres forming perivascular plexuses and nerve fibres grouped within the nerve fascicles. In the gallbladder`s fundus, body and neck, the TH + fibres formed mucosal, muscular and serosal nonganglionated nerve plexuses. Toluidine blue (TB) staining was used to confirm that the TH positive cells were mast cells. The number of THMC in the propria of gallbladder`s fundus, body and neck was significantly higher than in the muscular and serosal layers in both genders. The number of mast cells in the musculature was higher than in the serosa. The density and location of the THMC were similar to the TB positive (with gamma metachromasia) mast cells in both males and females, and statistically significant difference was not established. In conclusion, original data concerning the existence and localisation of catecholaminergic nerves and THMC distribution in the porcine gallbladder's wall are presented. The results could contribute to the body of knowledge of functional communication between autonomic nerves and mast cells in the gallbladder.

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Catecholamine-Containing Cells in the Nerve Plexus of the Guinea Pig Gallbladder

Cited by 14 publications

References 7 publications

Degeneration of Adrenergic Nerves in the Gail-Bladder of Cholecystitis Patients

Degeneration of Adrenergic Nerves in the Gail-Bladder of Cholecystitis Patients

Innervation of the extrahepatic biliary tract

Tyrosine hydroxylase positive nerves and mast cells in the porcine gallbladder

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