Catecholamine excretion by the healthy adult human

Becker, E. J.; Kreuzer, F.

doi:10.1007/bf00586479

Cited by 25 publications

(6 citation statements)

References 17 publications

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“…The results presented here confirm and extend those of other workers: our values for the urinary excretion of free noradrenaline and adrenaline in normal control subjects are similar to those reported by Becker & Kreuzer (1970) and Mabry & Warth (1969) and the decrease produced by recumbency has also been recorded (Euler, Luft & Sundin, 1955;Karki, 1956).…”

Section: Discussionsupporting

confidence: 95%

“…Several studies have been published recording normal urinary output of catecholamines and the effects of posture, exercise and diurnal changes (Euler, Hellner-Bjorkman & Orwhn, 1955;Karki, 1956;Becker & Kreuzer, 1970;Klepping, Goudonnet, Didier & Escousse, 1971). The need for such normal data prompted this investigation of further aspects of catecholamine excretion including diurnal variation and its relation to sodium excretion.…”

mentioning

confidence: 97%

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Factors Influencing the Urinary Excretion of Free Catecholamines in Man

Townshend¹,

Smith²

1973

Clinical Science

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1. The 24 h urinary excretion of noradrenaline and adrenaline is significantly lower in recumbent than ambulant normal subjects.2. A diurnal variation exists in catecholamine excretion, the lowest values occurring during sleep.3. Diurnal variation in sodium excretion parallels that in noradrenaline and adrenaline loss but the cycles can be separated by acute alterations in sleep/awake pattern. 4.Diurnal variation is lost during exercise, after myocardial infarction and was absent pre-operatively in a patient with a phaeochromocytoma. 5. Acute alterations in renal blood flow, diuresis, natriuresis and urinary acidification do not alter catecholamine excretion significantly.6. Urinary catecholamine excretion is related to physical activity and wakefulness; the normal diurnal variation is easily overriden by sustained sympatho-adrenal activity. Alterations in renal function in exercise or after myocardial infarction do not account for the observed increases in catecholamine excretion.

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Section: Discussionsupporting

confidence: 95%

mentioning

confidence: 97%

Factors Influencing the Urinary Excretion of Free Catecholamines in Man

Townshend¹,

Smith²

1973

Clinical Science

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“…This diurnal pattern also could be shown in this work on daily variations in the metabolics of L-DOPA-DA, NA-A and 5-HT. K&ki (1956) demonstrated an independence of catecholamine excretion rates from the urine volume, which is in agreement with our findings and that of Becker (1970).…”

Section: ~supporting

confidence: 95%

“…In depressed patients L-tryptophan and L-tyrosine was shown to change in response to the disease state . Kiirki (1956), yon Euler (1955), Becker (1970), Townshend (1973) and Winkel (1973) Therefore it was our intention to determine, whether there is an inversial diurnal rhythm in the metabolism of catecholamines and 5-HT or not in depression syndrom.…”

Section: Introductionmentioning

confidence: 99%

The daily rhythm of HVA, VMA, (VA) and 5-HIAA in depressionsyndrom

Riederer

Birkmayer

Neumayer

et al. 1974

J. Neural Transmission

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“…1.4) (-9 %), probably because the sex-difference in creatinine excretion (-30 % in women) is not accounted for by the difference (-24 %) between the mean body weight of men (68 kg) and women (52 kg). Accordingly, as previously pointed out by Becket and Kreuzer (1970), expression of results as/2g/ mg of creatinine in adults may lead to slightly overestimated figures in women, which could not reflect functional difference in the sympathoadrenal system in the two sexes. Thus, in the present report, data expressed as/2g/rag of creatinine have been considered to confirm results found as/2g/24 hours only in neonates and children but not in adults.…”

Section: Discussionmentioning

confidence: 85%

Sex-differences in catecholamine metabolites in human urine during development and at adulthood

Dalmaz

Peyrin

1982

J. Neural Transmission

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Adrenergic amines (dopamine [DA], norepinephrine [NE], epinephrine [E] and related compounds (DOPA, 3-methoxytyramine [MT], normetanephrine [NMN], metanephrine [MN], 3-5-dihydroxyphenylacetic acid [DOPAC], vanilmandelic acid [VMA] were analyzed in urine of human from one day to 40 years of age, in view to investigate the sex influence on catecholamine metabolism during life. In neonatal life (1 day to 3.5 months), the total amounts of urinary (E + MN) and (NE + NMN + VMA) were lower in girls than in boys, the former two compounds being mainly of adrenal medullary origin and the latter three coming largely from the sympathetic neurons. In adulthood, women excreted epinephrine (12.5 +/- 2.2 micrograms/24 hours) at lower levels then men (22.8 +/- 4.5 micrograms/24 hours) but no sex related differences occurred in the total amounts of urinary E + MN and NE + NMN + VMA. It is concluded from our study that, during the neonatal life, girls exhibit a lesser adreno-sympathetic maturity than boys, but full maturation of peripheral adrenergic sites is reached near to the fifth year of age in both sexes. The role of testosterone has been discussed. In adults, the lower epinephrine levels found in women urine do not seem to result from a sex difference in the degree of adrenergic maturity, but perhaps partly from an increased rate of epinephrine inactivation by catechol-O-methyltransferase.

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Catecholamine excretion by the healthy adult human

Cited by 25 publications

References 17 publications

Factors Influencing the Urinary Excretion of Free Catecholamines in Man

Factors Influencing the Urinary Excretion of Free Catecholamines in Man

The daily rhythm of HVA, VMA, (VA) and 5-HIAA in depressionsyndrom

Sex-differences in catecholamine metabolites in human urine during development and at adulthood

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