2004
DOI: 10.1124/pr.56.3.1
|View full text |Cite
|
Sign up to set email alerts
|

Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

8
658
2
20

Year Published

2007
2007
2024
2024

Publication Types

Select...
4
3

Relationship

0
7

Authors

Journals

citations
Cited by 890 publications
(688 citation statements)
references
References 192 publications
(209 reference statements)
8
658
2
20
Order By: Relevance
“…MAO-B has a higher preference for metabolism of phenylethylamine and is predominantly abundant in serotonergic and histaminergic neurons and glial cells . MAO activity is always accompanied by AR or ALDH that metabolizes unstable aldehyde intermediates [Eisenhofer et al, 2004].…”
Section: Metabolism Of Serotonin and Catecholaminesmentioning
confidence: 99%
See 2 more Smart Citations
“…MAO-B has a higher preference for metabolism of phenylethylamine and is predominantly abundant in serotonergic and histaminergic neurons and glial cells . MAO activity is always accompanied by AR or ALDH that metabolizes unstable aldehyde intermediates [Eisenhofer et al, 2004].…”
Section: Metabolism Of Serotonin and Catecholaminesmentioning
confidence: 99%
“…Although the conversion of PAH to tyrosine in dog liver was demonstrated in 1913 [Embden and Baldes, 1913], the first mammalian PAH was characterized around 1960. Similarly, the conversion of tyrosine to L-DOPA as the first step in catecholamine biosynthesis was postulated in 1939, but TH was first purified in 1964 [Nagatsu et al, 1964], the same year as the TH, tyrosine 3-hydroxylase or tyrosine 3-monooxygenase; TPH1, tryptophan 5-hydroxylase isoform 1 or tryptophan 5-monooxygenase isoform 1, classical form expressed in peripheral organs like gut, pineal gland, spleen, and thymus; TPH2, tryptophan 5-hydroxylase isoform 2 or tryptophan 5-monooxygenase isoform 2, also termed neuronal tryptophan hydroxylase (NTPH), neuronal or brain type expressed predominantly in brain stem (central nervous system); AADC, aromatic L-amino acid decarboxylase; wide expression in neuronal but also nonneuronal tissues; an exon 3 deleted splice variant with only 442 amino acids is widely expressed but results in an inactiveAADC isoform; gene symbol DDC: dopa decarboxylase (old gene symbol synonym is AADC); DbH, dopamine beta-hydroxylase; PNMT, phenylethanolamine N-methyltransferase; MAO-A, monoamine oxidase A; the oxidase activity is accompanied by aldehyde/aldose reductase (AR) an aldehyde/aldose dehydrogenase/oxidoreductase (ALDH) that metabolizes various unstable aldehyde intermediates; for details see Eisenhofer et al [2004]; COMT, catechol O-methyltransferase; SULT1A3: sulfotransferase 1A3; the same SULT1A3 protein is expressed from the two genes, duplicated on chromosome 16p, SULT1A3 and SULT1A4 (also see Metabolism of Serotonin and Catecholamines for more details).…”
Section: Aromatic Amino Acid Hydroxylasesmentioning
confidence: 99%
See 1 more Smart Citation
“…Both excess nicotinamide 1 and circulating norepinephrine 7 have previously been shown to be degraded through methylation, primarily in the liver. The findings that in normotensives, nicotinamide load significantly increased plasma concentrations of norepinephrine and Hcy while decreasing the levels of normetanephrine and betaine, suggest that excess nicotinamide may deplete liver methyl pool.…”
Section: Discussionmentioning
confidence: 99%
“…inactivation) of catecholamines, in CVD is unknown. Based on evidence that the inactivation of catecholamines is also mediated via SAM-dependent methylation (Figure 1), 7 which may be influenced by niacin due to a competition for labile methyl groups, we postulated that high niacin intake may contribute to increased circulating levels of catecholamines and subsequent development of CVD. To test this hypothesis, we investigated the effect of nicotinamide loading on the body's methylation status and methylation-mediated catecholamine degradation in both normotensives and hypertensives.…”
Section: Introductionmentioning
confidence: 99%