Catecholamine Metabolism in Affective Disorders

Greenspan, Kenneth

doi:10.1001/archpsyc.1969.01740240070009

Cited by 62 publications

(9 citation statements)

References 11 publications

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“…Because of this a number of groups have been interested in evaluating urinary MHPG as a reflection of brain NE metabolism in depressed patients. It has been reported that daily excretion of urinary MHPG is low in patients with endogenous depressions compared to controls , that urinary MHPG levels in depressed patients in crease after recovery (Greenspan et al, 1970), and that MHPG excretion is higher in patients in the manic phase than in the same or other patients in the depressed phase of bipolar af fective illness (Greenspan et al, 1970;Bond et al, 1972;Jones et al, 1973). The purpose of the present study was to examine the urinary excretion of MHPG in unipolar and bipolar depressed patients and in an age-matched group of normal controls.…”

Section: Introductionmentioning

confidence: 98%

Urinary MHPG in Subgroups of Depressed Patients and Normal Controls

Beckmann¹,

Goodwin²

1980

Neuropsychobiology

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3-Methoxy-4-hydroxyphenylglycol (MHPG), the urinary metabolite thought best to reflect brain norepinephrine metabolism, was studied in a large group of hospitalized depressed patients with primary affective disorder and in normal controls, as part of an ongoing effort to evaluate the role of central amine dysfunction in affective illness. Overall there was no difference in MHPG between the depressed patients and controls. However, within the depressed population the bipolar patients excreted significantly less MHPG than the unipolars and, as a group, the male bipolar patients had significantly lower MHPG than male controls. MHPG correlated positively with age, age of onset, ratings of anxiety and psychosis and, most importantly, with systolic blood pressure. These data support the concept of biological heterogeneity among individuals with major depressive disorders. However, the relationship between MHPG excretion and various psychological and physiological parameters is both intriguing and complex and warrants careful interpretation.

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Section: Introductionmentioning

confidence: 98%

Urinary MHPG in Subgroups of Depressed Patients and Normal Controls

Beckmann¹,

Goodwin²

1980

Neuropsychobiology

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“…1973;Post et al. 1977], Significant increase in urinary MHPG is also reported to be associated with the recovery from depressive episodes in selected groups of patients [Greenspan et al. 1970;Pickar et al.…”

Section: Introductionmentioning

confidence: 99%

Urinary MHPG, Stress Response, Personality Factors and Somatosensory Evoked Potentials in Normal Subjects and Patients with Major Affective Disorders

Buchsbaum¹,

Muscettola²,

Goodwin³

1981

Neuropsychobiology

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Stressful procedures are reported to increase urinary MHPG in both noraml and depressed patients. Bipolar depressed patients are alos shown to be especially pain tolerant in comparison to normals. In the present study, 12 depressed patiens (6 bipolar and 6 unipolar patients) and 10 normal volunteers had average evokded potentials recorded for visual and painful electrical stumuli. MHPG urinary excretion was measured during this session and during an unstimulated resting session on the home ward. Male normal volunteers showed a significant increase in urinary MHPG under stress, while no MHPG increment was noted for the depressed patient group. Depth of depression, assessed by the Zung and Beck scales, was found to be correlated with the reduced urinary MHPG response to stress. Possible interpretations of the results are discussed.

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“…In such cases, amine metabolites in urine, blood or CSF may be normal even with a manic picture. Interestingly, transient hypomanie symptoms have been observed in patients with endogenous depression who are receiving imipramine at a time when normetanephrine excretion was also observed during spontaneously occurring hypomanie episodes (Schildkraut et al, 1965;Greenspan et al, 1969Greenspan et al, , 1970. These data provide for evidence of an association between NE and mania, if not a caused relationship.…”

Section: Norepinephrinementioning

confidence: 99%

“…Clinically, it is useful to study whether manic depressive patients suffer from parkinsonism and whether all those who develop mania while on L-dopa have a bipolar history. Greenspan et al (1969) have reported overactivity of peripheral nervous system and adrenal medulla in manic patients. Volk et al (1972) have treated manies with (3-adrenergic blocker oxypronlol with reported success.…”

Section: Dopaminementioning

confidence: 99%

Treatment Approaches to Mania

Ananth¹

1976

Int Pharmacopsychiatry

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Treatment of manic episodes is an urgency because of the lack of insight and excessive psychomotor activity. Over the past two decades various new modes of pharmacological treatment of this condition has been reported. Along with them, biochemical findings in manic patients have been exhaustively investigated. Etiologically based pharmacological treatment of manic episodes will help us therapeutically in improving the condition of the patient and scientifically, to confirm or explore biochemical basis of manic episodes. The new innovative approaches for the treatment of manic episodes need to be applied in treating therapy-resistant patients. Included in this paper are treatment approaches based on norepinephrine, dopamine, acetylcholine, serotonin, γ-aminobutyric acid and permissive hypothesis, peripheral autonomic imbalance, endocrine abnormalities, electrolyte disturbances, paradoxical response, and cyclic AMP. In addition, use of antidepressants and pyrotherapy is described.

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Catecholamine Metabolism in Affective Disorders

Cited by 62 publications

References 11 publications

Urinary MHPG in Subgroups of Depressed Patients and Normal Controls

Urinary MHPG in Subgroups of Depressed Patients and Normal Controls

Urinary MHPG, Stress Response, Personality Factors and Somatosensory Evoked Potentials in Normal Subjects and Patients with Major Affective Disorders

Treatment Approaches to Mania

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