Catecholamine metabolism in the rat brain after short and long term lithium administration

Poitou, P; Bohuon, C

doi:10.1111/j.1471-4159.1975.tb04362.x

Cited by 34 publications

(6 citation statements)

References 23 publications

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“…There is no agreement in the literature concerning the effect of repeated administration of lithium on concentrations of DA and metabolites in the rat brain (e.g. Baptista et al, 1993;Berggren, 1985;Bliss and Ailion, 1970;Bowers and Rozitis, 1982;Carli et al, 1994;Corrodi et al, 1969;Friedman and Gershon, 1973;Gottberg et al, 1989;Ho et al, 1970;Mclntyre, 1983;Otero-Losada and Rubio, 1985;Poitou and Bohuon, 1975;Schubert, 1973).…”

Section: Introductionmentioning

confidence: 96%

Adaptive changes in the rat dopaminergic transmission following repeated lithium administration

Dziedzicka-Wasylewska

Maćkowiak

Fijat

et al. 1996

J. Neural Transmission

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In the present study the alterations in the contents of dopamine (DA) and metabolites, as well as in the levels of mRNA coding for DA receptor D2, were determined in the rat striatum (STR) and nucleus accumbens septi (NAS), in correlation with the duration of lithium administration. Single or subchronic (3 days) administration of lithium produced less consistent effects as far as the levels of DA and metabolites are concerned; however, following 7 or 14 days of lithium administration, the DA release from terminals was significantly attenuated and the effect was more pronounced in NAS. After the same time of treatment, the increase in the levels of mRNA coding for the D2 receptor was increased; this might be interpreted as an adaptive change to the decreased dopaminergic transmission following the prolonged administration of lithium.

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Section: Introductionmentioning

confidence: 96%

Adaptive changes in the rat dopaminergic transmission following repeated lithium administration

Dziedzicka-Wasylewska

Maćkowiak

Fijat

et al. 1996

J. Neural Transmission

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“…Alterations in 5-HIAA levels may not be detected if transport of 5-HIAA from the brain was modified. However, Perez-Cruet et al (1971) Poitou & Bohuon (1975) have shown decreases in dopamine synthesis following chronic Li; in contrast. Hesketh et al (1978) found an increased turnover in striatal dopamine.…”

Section: Introduction Methodsmentioning

confidence: 99%

Effect of Low‐dose Lithium Administration and Subsequent Withdrawal on Biogenic Amines in Rat Brain

Ahluwalia

Singhal

1980

British J Pharmacology

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The effects of low‐dose lithium administration (2 mEq/kg, daily) and its subsequent withdrawal have been examined with reference to changes in biogenic amine systems in several discrete regions of rat brain. Increased levels of striatal tyrosine and midbrain tryptophan were found following lithium administration together with slight decreases in striatal tyrosine hydroxylase and midbrain tryptophan hydroxylase activities. Withdrawal resulted in a decrease in tyrosine content with increased tyrosine hydroxylase activity, whilst tryptophan levels and tryptophan hydroxylase activity were increased. Lithium treatment and withdrawal resulted in altered levels of noradrenaline and dopamine, these changes being regionally variable. 3‐Methoxy‐4‐hydroxyphenylglycol content was depressed in both treated and withdrawal rats as were 3,4‐dihydroxyphenylacetic acid levels. Homovanillic acid decreased as a result of lithium treatment, but was greatly elevated in the withdrawal group. 5‐Hydroxytryptamine content decreased in some brain regions following lithium treatment with return towards control values in withdrawal rats. 5‐Hydroxyindoleacetic acid levels also displayed a regional variation as a result of lithium treatment and withdrawal. The implications of these observations in elucidating the pharmacological effect of lithium treatment and its subsequent withdrawal are discussed.

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“…However, it has been reported to interfere with the catecholaminergic system and neurotransmission in the central nervous system, and it has been demonstrated that it alters the metabolism of noradrenaline in rat brain, enhancing the destruction of the amine by monoamine oxidases (Schildkraut et al 1966;Corrodi et a1 1967;Schanberg et a1 1967;Greenspan et al 1970). Noradrenaline turnover is greatly enhanced in rat brain and slightly in the heart by lithium in doses in the therapeutic range (Stern et a1 1969;Poitou & Bohuon 1975). An increased noradrenaline uptake by rat isolated synaptosomes has been reported after chronic lithium administration (Colburn et al 1967); on the other hand, acute lithium administration does not modify noradrenaline uptake into rat brain in-vivo (Schanberg et a1 1967;Schildkraut et al 1969) or invitro (Katz et a1 1968).…”

mentioning

confidence: 99%

“…It has been suggested that lithium treatment induces a reduction in catecholamine release from nerve terminals (Poitou & Bohuon 1975). Katz et al (1968), Katz & Kopin (1969) and Bindler et al (1971) have observed that lithium decreases the release of noradrenaline induced by electrical field stimulation from rat brain slices and cat spleen.…”

mentioning

confidence: 99%

Effect of lithium chloride on the neurotransmitter release from adrenergic nerve terminals of guinea-pig atria

Mantelli

Ledda

1989

Journal of Pharmacy and Pharmacology

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Lithium chloride at 1 and 10 mM produced a dose-dependent inhibition of the cardiac response to field stimulation of the adrenergic nerve terminals, without affecting myocardial contractility in electrically stimulated guinea-pig atria. This effect was calcium-independent and was also present in preparations superfused with 10 mM myoinositol. Moreover, 10 mM lithium chloride reduced the positive inotropic effect of tyramine. These results indicate that lithium reduces the evoked release of noradrenaline from the adrenergic nerve endings, probably lowering the content of releasable neurotransmitter.

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Catecholamine metabolism in the rat brain after short and long term lithium administration

Cited by 34 publications

References 23 publications

Adaptive changes in the rat dopaminergic transmission following repeated lithium administration

Adaptive changes in the rat dopaminergic transmission following repeated lithium administration

Effect of Low‐dose Lithium Administration and Subsequent Withdrawal on Biogenic Amines in Rat Brain

Effect of lithium chloride on the neurotransmitter release from adrenergic nerve terminals of guinea-pig atria

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