Catecholamines and mania: The effect of alpha‐methyl‐para‐tyrosine on manic behavior and catecholamine metabolism

Brodie, H. Keith H.; Murphy, Dennis L.; Goodwin, Frederick K.; Bunney, William E.

doi:10.1002/cpt1971122part1218

Cited by 101 publications

(38 citation statements)

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“…At 4 g per day, AMPT induced cerebrospinal fluid HVA depletion (68 to 77%, Brodie et al 1971) similar to the one measured in the plasma in this study (70 Ϯ 12%). Following AMPT, cerebrospinal fluid HVA depletion reflects striatal dopamine depletion (Mignot and Laude 1985).…”

Section: Discussionsupporting

confidence: 86%

Imaging D2 Receptor Occupancy by Endogenous Dopamine in Humans

Laruelle

D’Souza

Baldwin

et al. 1997

Neuropsychopharmacology

251

193

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Section: Discussionsupporting

confidence: 86%

Imaging D2 Receptor Occupancy by Endogenous Dopamine in Humans

Laruelle

D’Souza

Baldwin

et al. 1997

Neuropsychopharmacology

251

193

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“…86 In an early treatment study on symptomatic depressed patients, all three patients had a depressive response to AMPT. 78 However, this finding seems to be anomalous, as a later study found no mood change in a sample of 17 unmedicated symptomatic depressed patients. 85 Combined AMPT and ATD had no effect on mood in a sample of 13 unmedicated depressed patients.…”

Section: Acute Tryptophan Depletionmentioning

confidence: 92%

“…77 Daily administration of AMPT (1-4 g/day) generally reduces urinary and CSF levels of MHPG and HVA (CA metabolites) by more than 50%. CSF levels of 5-HIAA (metabolite of 5-HT) remain unchanged, 78 indicating that the effects are specific. CA metabolite levels are assumed to reach their minimum within 2-3 days after starting AMPT administration and are normalized within 3-4 days after withdrawal of the drug.…”

Section: Acute Tryptophan Depletionmentioning

confidence: 99%

“…Mood state returned to baseline levels after discontinuation of the drug, except for three manic patients who retained the reduction in symptoms during the 5-day post-AMPT observational period. 78,80 In a treatment study with 20 patients with essential hypertension, six had a history of depression. Three of these depressionprone patients experienced increased agitation after receiving AMPT, requiring withdrawal of AMPT treatment.…”

Section: Acute Tryptophan Depletionmentioning

confidence: 99%

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Monoamine depletion in psychiatric and healthy populations: review

2003

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A number of techniques temporarily lower the functioning of monoamines: acute tryptophan depletion (ATD), alpha-methyl-para-tyrosine (AMPT) and acute phenylalanine/tyrosine depletion (APTD). This paper reviews the results of monoamine depletion studies in humans for the period 1966 until December 2002. The evidence suggests that all three interventions are specific, in terms of their short-term effects on one or two neurotransmitter systems, rather than on brain protein metabolism in general. The AMPT procedure is somewhat less specific, affecting both the dopamine and norepinephrine systems. The behavioral effects of ATD and AMPT are remarkably similar. Neither procedure has an immediate effect on the symptoms of depressed patients; however, both induce transient depressive symptoms in some remitted depressed patients. The magnitude of the effects, response rate and quality of response are also comparable. APTD has not been studied in recovered major depressive patients. Despite the similarities, the effects are distinctive in that ATD affects a subgroup of recently remitted patients treated with serotonergic medications, whereas AMPT affects recently remitted patients treated with noradrenergic medications. The evidence also suggests that ATD and APTD affect different cognitive functions, in particular different memory systems. Few studies investigated cognitive effects of the procedures in patients. Patients who are in remission for longer may also be vulnerable to ATD and AMPT, but the relationship with prior treatment is much weaker. For these patients, individual vulnerability markers are the more important determinants of depressive response, making these techniques potentially useful models of vulnerability to depression. Molecular Psychiatry (2003) 8, 951-973.

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“…1971;Ahlenius et al 1973; 0893-133X/93/$0 .00 Pozuelo 1976;Nasrallah et al 1977}. In addition, it has been noted that discontinuation of AMPT treatment is associated with insomnia and decreased total sleep (Bunney et al 1971(Bunney et al , 1977. This observed rebound in somnia has been postulated to be secondary to an in crease in catecholaminergic activity.…”

mentioning

confidence: 99%