Catecholamines and the Regulation of Body Temperature

Myers, R.D.

doi:10.1007/978-3-642-67505-8_14

Cited by 12 publications

(2 citation statements)

References 64 publications

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“…These stressors include starvation, in which catecholamines regulate the mobilization of stored metabolites such as lipids and glycogen, and thermoregulation, in which NE induces heat production largely from brown adipose tissue. For example, upon exposure to cold ambient temperatures, afferent nerve fibers from the skin signal to pre-optic hypothalamic nuclei [16] and subsequent hypothalamus activation results in the signaling to the brown adipose tissue to induce adaptive thermogenesis [17]. This process, mediated primarily by NE, facilitates a rapid rise in metabolic rate and an elevation in body temperature [18].…”

Section: The Classical Stress Pathway - the Sympathetic Nervous Systementioning

confidence: 99%

A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response

Eng

Kokolus

Reed

et al. 2014

Cancer Immunol Immunother

138

102

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Long conserved mechanisms maintain homeostasis in living creatures in response to a variety of stresses. However, continuous exposure to stress can result in unabated production of stress hormones, especially catecholamines, which can have detrimental health effects. While the long-term effects of chronic stress have well known physiological consequences, recent discoveries have revealed that stress may affect therapeutic efficacy in cancer. Growing epidemiological evidence reveals strong correlations between long term survival and cancer progression and β-blocker usage in patients. In this review, we summarize the current understanding of how the catecholamines, epinephrine and norepinephrine, affect cancer cell survival and tumor progression. We also highlight new data exploring the potential contributions of stress on immunosuppression in the tumor microenvironment and the implications of these findings for the efficacy of immunotherapies.

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Section: The Classical Stress Pathway - the Sympathetic Nervous Systementioning

confidence: 99%

A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response

Eng

Kokolus

Reed

et al. 2014

Cancer Immunol Immunother

138

102

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“…Under standard housing temperatures, laboratory mice continuously lose heat to their environment and, thus, must expend more metabolic energy to generate sufficient heat to maintain their body temperature. The response to mild cold stress is regulated specifically by norepinephrine (NE), a stress hormone which can drive heat production through adaptive thermogenesis and other metabolic changes (15,16). This metabolic stress creates several important physiological changes in mice (14,17).…”

Section: Introductionmentioning

confidence: 99%

Housing temperature influences the pattern of heat shock protein induction in mice following mild whole body hyperthermia

Eng

Reed

Kokolus

et al. 2014

International Journal of Hyperthermia

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Purpose Researchers studying the response of mice to stress generally use mice housed under standard, nationally-enforced conditions as controls. Few investigators are concerned whether basic, physical aspects of mouse housing could also be a source of stress, capable of influencing the subsequent impact of an experimentally applied stressor. We have recently become aware of the potential for standard housing conditions to influence important physiological and immunological properties in mice. Materials and Methods Here, we sought to determine whether housing mice at standard temperature (ST; 22°C) versus thermoneutral temperature (TT; 30°C) influences baseline expression of heat shock proteins (HSPs) and their typical induction following a whole body heating. Results There were not significant differences in baseline expression of HSPs at ST and TT. However, in several cases, we induction of HSP70, HSP110, and HSP90 in tissues of mice maintained at ST was greater than at ST, following 6 hours of heating which elevated core body temperature to 39.5°C. This loss of HSP induction was also obtained when mice housed at ST were given propranolol, a β-adrenergic receptor antagonist, used clinically to treat hypertension and stress. Conclusions Taken together, these data show that housing temperature has a significant influence on the expression of HSPs in mice after whole body heating and should be considered when stress responses are studied in mice.

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Neurochemical Aspects of Thermoregulation

Myers

Lee

1989

Advances in Comparative and Environmental Physiology

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Catecholamines and the Regulation of Body Temperature

Cited by 12 publications

References 64 publications

A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response

A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response

Housing temperature influences the pattern of heat shock protein induction in mice following mild whole body hyperthermia

Neurochemical Aspects of Thermoregulation

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