Catecholamines and their metabolites in the brain and urine of rats with experimental Parkinson’s disease

Чехонин, В. П.; Baklaushev, V. P.; Kogan, Boris; Savchenko, Ekaterina; Лебедев, С. В.; Man'kovskaya, I. V.; Филатова, Т. С.; Yusupova, I. U.; Dmitrieva, T. B.

doi:10.1007/bf02766101

Cited by 12 publications

(9 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, while previous work suggested that urinary dopamine excretion is reflective of central nervous system dopamine levels (Chekhonin et al, 2000; Marc et al, 2008), it is important to acknowledge our use of urinary dopamine as a proxy measure may limit the inferences we can make about the associations between CNS dopamine, sleep, and immune status (Hinz et al, 2011). In addition, we were limited in that we had access to only one immune measure (CD4 count) and one dopamine measure.…”

Section: Discussionmentioning

confidence: 99%

Self-reported sleep disturbance is associated with lower CD4 count and 24-h urinary dopamine levels in ethnic minority women living with HIV

Seay

McIntosh

Fekete

et al. 2013

Psychoneuroendocrinology

View full text Add to dashboard Cite

Background Sleep disturbance is associated with dopamine dysregulation, which can negatively impact immune status. Individuals living with HIV experience more sleep difficulties, and poor sleep may compound immune decrements associated with HIV infection. Little research has examined associations between sleep, dopamine, and immune status (CD4 count) in individuals with HIV. As ethnic minority women living with HIV (WLWH) are at heightened risk for HIV disease progression, we related sleep reports to both CD4 count and dopamine levels in a cohort of ethnic minority WLWH. Methods Participants were 139 low-income WLWH (ages 20–62; 78.3% African-American or Caribbean) who reported both overall sleep quality and sleep disturbance on the Pittsburgh Sleep Quality Index (PSQI). CD4 count and HIV viral load were measured via morning peripheral venous blood samples, and concentrations of dopamine were measured via 24-hour urine collection. Covariates included HIV viral load, length of time since HIV diagnosis, HAART adherence, perceived stress and depression. Results After controlling for all covariates, greater sleep disturbance was associated with significantly lower CD4 count (β = −.20, p = .03) and lower levels of dopamine (β = −.25, p = .04). Poorer overall sleep quality was marginally associated with lower CD4 count (β = −.16, p = .08), and was not associated with dopamine. Conclusion Our analyses suggest that sleep disturbance is independently related with immune status and dopamine levels in WLWH. Lower levels of dopamine may indicate neuroendocrine dysregulation and may impact immune and health status. Results highlight sleep disturbance rather than overall sleep quality as potentially salient to neuroendocrine and immune status in ethnic minority WLWH.

show abstract

Section: Discussionmentioning

confidence: 99%

Self-reported sleep disturbance is associated with lower CD4 count and 24-h urinary dopamine levels in ethnic minority women living with HIV

Seay

McIntosh

Fekete

et al. 2013

Psychoneuroendocrinology

View full text Add to dashboard Cite

show abstract

“…The concentration of DA in blood is less than 130 pM, while in human cerebrospinal fluid and urine the levels of DA are 5 nM [31]. Chekhonin et al concluded that in experimental parkinsonism, the measurement of catecholamines and their metabolites in urine can be considered as a biomarker to evaluate the situation of the dopaminergic nigrostriatal system of the brain [32].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Electrochemical and Optical Sensing of Dopamine

Eddin

Fen

2020

Sensors

View full text Add to dashboard Cite

Nowadays, several neurological disorders and neurocrine tumours are associated with dopamine (DA) concentrations in various biological fluids. Highly accurate and ultrasensitive detection of DA levels in different biological samples in real-time can change and improve the quality of a patient’s life in addition to reducing the treatment cost. Therefore, the design and development of diagnostic tool for in vivo and in vitro monitoring of DA is of considerable clinical and pharmacological importance. In recent decades, a large number of techniques have been established for DA detection, including chromatography coupled to mass spectrometry, spectroscopic approaches, and electrochemical (EC) methods. These methods are effective, but most of them still have some drawbacks such as consuming time, effort, and money. Added to that, sometimes they need complex procedures to obtain good sensitivity and suffer from low selectivity due to interference from other biological species such as uric acid (UA) and ascorbic acid (AA). Advanced materials can offer remarkable opportunities to overcome drawbacks in conventional DA sensors. This review aims to explain challenges related to DA detection using different techniques, and to summarize and highlight recent advancements in materials used and approaches applied for several sensor surface modification for the monitoring of DA. Also, it focuses on the analytical features of the EC and optical-based sensing techniques available.

show abstract

“…As previously discussed, the relationship between central, peripheral, and urinary catecholamines is unclear; therefore, we cannot determine the specific origin of the NE and DA assessed in this study. Nonetheless, evidence indicating that past studies have successfully used urinary NE and DA analysis to provide markers of central and peripheral functioning [47–52] suggests that our preliminary findings may provide insight into the relationship between NE and DA and female sexual arousal responses during different emotion‐motivation states. Future studies may wish to assess NE and homovanillic acid (a DA metabolite), in plasma, as this methodology may offer a more accurate assessment of these catecholamines [43], although limitations of this methodology will also need to be carefully evaluated.…”

Section: Discussionmentioning

confidence: 77%

“…The study's authors concluded that peripheral sympathetic elevation in DA activity might represent a marker for central DA hyperactivity. Similarly, daily urinary excretion of NE and DA decreased significantly in denervated rats undergoing experimental Parkinson's disease, offering promise for evaluating the concentration of striatal DA during treatment for Parkinson's disease (characterized by low DA in the striatum) in experimental studies [48]. In humans, elevated spot NE urinary levels have shown a close relationship with women's stress over the course of the workday [49].…”

Section: Introductionmentioning

confidence: 99%

Emotional States of Love Moderate the Association Between Catecholamines and Female Sexual Responses in the Laboratory

Dundon

Rellini

2012

The Journal of Sexual Medicine

View full text Add to dashboard Cite

Introduction Research suggests that there are three interrelated, yet distinct, emotion motivation brain systems for human love (lust, romantic love, and attachment), each associated with a unique catecholaminergic and hormonal profile. Of interest for the current study are norepinephrine (NE) and dopamine (DA), which have a hypothesized connection with romantic love. As NE and DA are also known to facilitate sexual arousal, it is plausible that NE and DA may have a greater positive association with the sexual arousal responses of women in romantic love compared with women in lust. Aim This study investigated if the effects of NE and DA activity on sexual arousal responses would differ depending on emotion motivation state (Lust or Romantic). Main Outcome Measures Physiological sexual arousal was assessed by photoplethysmography and subjective sexual arousal was assessed with a participant controlled lever. Methods Seventeen women were included in the Lust group and 29 in the Romantic group. All participants provided a urine sample (to assess NE and DA) and completed a psychophysiological assessment. Results Elevated NE was positively and significantly associated with greater subjective and physiological sexual arousal for the Lust group, but not for the Romantic group. Similarly, elevated DA was positively and significantly associated with greater subjective sexual arousal for the Lust group, but not for the Romantic group. Conclusions The sexual arousal responses of women in the Lust group, but not in the Romantic group, were positively and significantly associated with elevated NE and DA. It is feasible that, when women are seeking a partner (Lust), NE and DA may facilitate attention toward sexually relevant stimuli.

show abstract

Catecholamines and their metabolites in the brain and urine of rats with experimental Parkinson’s disease

Cited by 12 publications

References 3 publications

Self-reported sleep disturbance is associated with lower CD4 count and 24-h urinary dopamine levels in ethnic minority women living with HIV

Self-reported sleep disturbance is associated with lower CD4 count and 24-h urinary dopamine levels in ethnic minority women living with HIV

Recent Advances in Electrochemical and Optical Sensing of Dopamine

Emotional States of Love Moderate the Association Between Catecholamines and Female Sexual Responses in the Laboratory

Contact Info

Product

Resources

About