Categorizing Asthma Severity: An Overview of National Guidelines

Colice, Gene

doi:10.3121/cmr.2.3.155

Cited by 51 publications

(43 citation statements)

References 75 publications

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“…18 Studies on severe asthma have used a variety of definitions for severe disease that differ in their requirement for frequency and severity of symptoms and exacerbations, as well as dose of corticosteroids. 19 We chose to use the ATS workshop definition of severe asthma to identify subjects with severe asthma for SARP.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program

Moore¹,

Bleecker²,

Curran‐Everett

et al. 2007

Journal of Allergy and Clinical Immunology

846

782

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Section: Discussionmentioning

confidence: 99%

Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program

Moore¹,

Bleecker²,

Curran‐Everett

et al. 2007

Journal of Allergy and Clinical Immunology

846

782

View full text Add to dashboard Cite

show abstract

“…Unlike control, asthma severity is defined as a relatively stable [17, 37, 40] underlying characteristic of the individual [37], which represents the pathophysiology of the disease [35,36,37]. Findings from the present review reinforce that each guideline branded their assessment of asthma by emphasizing either asthma control or severity [41]. Based on the 3 stages of assessment, the guidelines were classified according to decreasing emphasis on asthma severity and the increasing focus on control: US-02, GINA-05, Canada, UK, US-07, Australia and GINA-06.…”

Section: Discussionmentioning

confidence: 88%

“…This approach acknowledges that severity is a determinant of asthma control [38, 40, 42] but does not dictate the means to achieve it [44]. It supports the possibility to have severe asthma that is well controlled, or conversely, mild asthma that is not well controlled [17, 40, 41], as patients classified as having mild asthma may report impaired quality of life [43]. Focusing on control may improve patient perceptions and expectations that are commonly low in children [16, 25, 45, 46], caregivers [22] and clinicians [15, 46, 47].…”

Section: Discussionmentioning

confidence: 99%

International Differences in Asthma Guidelines for Children

Cope

Ungar

Glazier

2008

Int Arch Allergy Immunol

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Background: Over the last decade, a number of clinical practice guidelines that include guidance for the management of pediatric asthma have been introduced. The consistency across pediatric asthma guidelines is unknown and the emphasis on establishing asthma control may vary. The objective of this paper was to depict the evolution of guidelines for pediatric asthma and to compare current international guidelines in terms of their organization, presentation of evidence and consideration of children, with special emphasis on definitions of asthma control and severity. Methods: A systematic search to identify asthma guidelines was conducted, and guidelines were searched for pediatric terms. The approaches used by guidelines to define assessments of asthma severity and control were compared between the United States, the Global Initiative for Asthma, Canada, the United Kingdom and Australia. Results: Pediatric considerations in the management of asthma have been integrated into the various guidelines to different degrees and through varied strategies. There were differences in the conceptual and operational approach used to assess asthma which emphasized either asthma severity or control. Conclusions: It will be important for future guidelines to clearly define whether the primary assessment parameter is asthma severity or control. Delineating the guideline development process and supporting evidence may improve transparency, consistency and guideline adherence.

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“…Clinically, asthma attacks are classified as mild, moderate and severe [41]. In this work, asthma attack was simulated by reducing the reference cross-section area S 0 in Equation (3) for all terminal tubes and by reducing the effective radius of the alveolar volume r e f in Equation (12) as:…”

Section: Asthma Modelmentioning

confidence: 99%

Multiscale CT-Based Computational Modeling of Alveolar Gas Exchange during Artificial Lung Ventilation, Cluster (Biot) and Periodic (Cheyne-Stokes) Breathings and Bronchial Asthma Attack

et al. 2017

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An airflow in the first four generations of the tracheobronchial tree was simulated by the 1D model of incompressible fluid flow through the network of the elastic tubes coupled with 0D models of lumped alveolar components, which aggregates parts of the alveolar volume and smaller airways, extended with convective transport model throughout the lung and alveolar components which were combined with the model of oxygen and carbon dioxide transport between the alveolar volume and the averaged blood compartment during pathological respiratory conditions. The novel features of this work are 1D reconstruction of the tracheobronchial tree structure on the basis of 3D segmentation of the computed tomography (CT) data; 1D−0D coupling of the models of 1D bronchial tube and 0D alveolar components; and the alveolar gas exchange model. The results of our simulations include mechanical ventilation, breathing patterns of severely ill patients with the cluster (Biot) and periodic (Cheyne-Stokes) respirations and bronchial asthma attack. The suitability of the proposed mathematical model was validated. Carbon dioxide elimination efficiency was analyzed in all these cases. In the future, these results might be integrated into research and practical studies aimed to design cyberbiological systems for remote real-time monitoring, classification, prediction of breathing patterns and alveolar gas exchange for patients with breathing problems.

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Categorizing Asthma Severity: An Overview of National Guidelines

Cited by 51 publications

References 75 publications

Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program

Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program

International Differences in Asthma Guidelines for Children

Multiscale CT-Based Computational Modeling of Alveolar Gas Exchange during Artificial Lung Ventilation, Cluster (Biot) and Periodic (Cheyne-Stokes) Breathings and Bronchial Asthma Attack

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