Cathelicidin-HG Alleviates Sepsis-Induced Platelet Dysfunction by Inhibiting GPVI-Mediated Platelet Activation
Weichen Xiong,
Jinwei Chai,
Jiena Wu
et al.
Abstract:Platelet activation contributes to sepsis development, leading to microthrombosis and increased inflammation, which results in disseminated intravascular coagulation and multiple organ dysfunction. Although Cathelicidin can alleviate sepsis, its role in sepsis regulation remains largely unexplored. In this study, we identified Cath-HG, a novel Cathelicidin from
Hylarana guentheri
skin, and analyzed its structure using nuclear magnetic resonance spectroscopy. The modulatory effect of Cath… Show more
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