Catheter-Associated Bacteria Urinary Tract Infection and Antibiotic Susceptibility Pattern in a Tertiary Hospital, in Ghana

Abstract

Background: This study seeks to identify the prevalence of catheter associated urinary infection and the type of bacteria that are associated with this infection, as well as the antibiotic susceptibility patterns of the organisms isolated. This would guide the choice of antibiotics when there is catheter associated urinary tract infection. Method: From 1 November 2015-31 April 2016 a cross-sectional study was conducted among patients with urinary catheter in-situ. Urine samples collected were processed and cultured on CLED agar plates. Pure colonies of isolated organism were Gram and Biochemically characterized. A disc diffusion antibiotic susceptibility determined by Kirby-Bauer disc diffusion method was performed on each uropathogen isolated. Data obtained was cleaned, analyzed and presented. Result: There were 122 study subjects of which, 73 (59.8%) were males and 49 (40.2%) were females. Their median age was 42.5 (range 33-65) years. Significant bacterial growth was obtained in 88 (72.1%) of the urine specimen cultured of which males constituted 48 (54.5%) and females 40 (45.5%). The most prevalent uropathogens isolated were Escherichia coli 41 (46.6%), Klebsiella spp. 18 (20.6%), Pseudomonas aeruginosa 10 (11.4%), Enterobacter spp. 6 (6.8%) and Staphylococcus aureus 5 (5.8%). Bacterial isolates showed some susceptibility to Amikacin 73 (83.0%), Levofloxacin 34 (38.6%) and Ciprofloxacin 26 (29.5%) respectively. The uropathogens were least susceptible to Gentamicin 3 (3.4%), Ampicillin 3 (3.4%) and Cefuroxime 1 (1.1%) respectively. Conclusion: Catheter associated bacterial urinary tract infection (CABUTI)

Microbial Profile and Antibiotic Resistance Pattern of Urine and Biofilm Pathogens Isolated from Catheterized Patients at Komfo Anokye Teaching Hospital, Kumasi, Ghana

“…Prevalence of CAUTI in this study was 74.29% which is in line with 74.6% in Nigeria [18], 73.3% in Pakistan [22], 72.1% in northern Ghana [15] and 76.6% in Accra [14]. However, higher prevalence rate than this study was recorded among CAUTI patients in Nigeria [13] [18] but lower rates (17.5%) and (43.5%) than this study were recorded in Egypt and India respectively [7] [25].…”

Analysis of Etiology and Risk Factors of Catheter-Associated Urinary Tract Infection in Critically Ill Patients and Research on Corresponding Prevention and Nursing Measures

“…Ill Patients With the extension of permanent catheters in ICU patients, the incidence of CAUTI also increases. This is because the permanent urinary catheter destroys the normal environment of the urethra, and the immune system weakens the phagocytosis of neutrophils, which affects the physiological role of the bladder on bacteria, making it easier for bacteria to enter the bladder and ureter, and the development of organs in the system and reproduction can cause infection [11,12]. At the same time, bacterial biofilms formed by bacteria on the urethral surface increase bacterial resistance to antimicrobial agents and host immune function, leading to fever, urethral stimulation, bladder inflammation, and even, urethral-associated infections.…”

Results of an Eight Year Long Practice of Saline Bipolar Transurethral Resection of Prostate

“…Chronic urinary retention and urethro-vesical catheterization had led to preoperative urinary infection in 5.8% patients. Like in Yenli's study [13], Escherichia coli was the most frequent causative germ. Despite antibiotic resistance issue, preoperative infection must be correctly treated before the procedure is carried out, to avoid in the TURP patients, complications such as prostatitis, orchitis, pyelonephritis, or septicemia.…”