Catheter-associated blood stream infections due to Candida pararugosa in a patient with acute myeloid leukemia: A case report

Isolation and identification of Wickerhamiella tropicalis from blood culture by MALDI-MS

“…The mortality of non- Candida albicans species in pediatric patients with malignancies was 26.3% between 2015 and 2019 ( Vasileiou et al., 2020 ). The previous studies reported that the 5 patients with W. pararugosa bloodstream infections were immunocompromised because of malignancy, sarcoma, surgery, and leukemia, and 2 of the 5 patients could not be cured ( Nasri et al., 2023 ). Similarly for W. tropicalis infections, accurate and rapid diagnosis of infection in immunocompromised patients is critical.…”

“…Wickerhamialla species show intrinsically intermediate resistance/resistance to fluconazole. W. pararugosa clinical isolates causing bloodstream infections had MICs of 4 to 8 μg/mL against fluconazole ( Taj-Aldeen et al., 2014 ; El Helou and Palavecino, 2017 ; Noni et al., 2020 ; Nasri et al., 2023 ). W. infanticola isolate from environmental sample had MICs of 4 μg/mL against fluconazole ( Maciel et al., 2019 ).…”

“…Previous studies have reported that W. pararugosa causes bloodstream infections. These species were detected in a six-month-old male with intrauterine growth in Qatar in 2006 ( Taj-Aldeen et al., 2014 ), a three-year-old female with acute lymphoblastic leukemia in Greece in 2008 ( Noni et al., 2020 ), a five-year-old male in Qatar in 2010 ( Taj-Aldeen et al., 2014 ), a 39-year-old female with morbid obesity in the United States in 2017 ( El Helou and Palavecino, 2017 ), and a three-year-old male with acute myeloid leukemia in Iran in 2022 ( Nasri et al., 2023 ). Though Wickerhamiella tropicalis was first isolated from environmental samples in 2020 ( Sakpuntoon et al., 2020 ), it has never been isolated from human samples.…”