Catheter-directed therapies for pulmonary embolism: considerations for patients with patent foramen ovale

Chockalingam, Arun; Nezami, Nariman; Murali, Nikitha; Mojibian, Hamid; Pollak, Jeffrey; Weiss, Clifford R.

doi:10.1007/s11239-020-02189-2

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…Successful treatment of PE in patients with PFO has been previously documented in case reports using surgical embolectomy, systemic or catheter-based thrombolysis (Chockalingam et al, 2020;Barbaryan et al, 2019). However, there are no current guidelines for management of PE in PFO patients.…”

Section: Discussionmentioning

confidence: 99%

“…While there are multiple case reports on application of catheter based interventions in patients with concurrent PE and PFO, there is no report of MT devices as alternative options in this population (Chockalingam et al, 2020). This case series hence aimed to focus on safety and efficacy of MT using the Inari FlowTriever System in patients with concurrent acute PE and PFO.…”

Section: Introductionmentioning

confidence: 99%

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Mechanical thrombectomy for pulmonary embolism in patients with patent foramen Ovale

et al. 2020

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Background The current level of evidence for mechanical thrombectomy (MT) of pulmonary embolism (PE) in patients with patent foramen ovale (PFO) is limited. Results This was a retrospective analysis of 9 patients with PFO and acute high-risk or intermediate-high-risk PE, 6 with intermediate-high risk and 3 with high-risk PE. All underwent MT using the Inari FlowTriever System from Dec 2018 to November 2019. Six of these patients had confirmed deep venous thrombosis. The technical and clinical success rate for MT in all patients was 100% and 77.8%, respectively. Right-heart strain improved in 6/8 patients on follow-up echocardiography. Mean main pulmonary artery (MPA) pressure significantly decreased after MT (p < 0.012). One patient presented with altered mental status (somnolence and disorientation) prior to coronary artery angiogram and thrombectomy, developed a middle cerebral artery embolic stroke 1 day after MT, and recovered with minor sequalae and later was discharged. There was no in-hospital mortality. Conclusions MT using FlowTriever was feasible and safe, successfully improving MPA pressure in patients presenting with concurrent PFO and PE.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mechanical thrombectomy for pulmonary embolism in patients with patent foramen Ovale

et al. 2020

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FlowTriever System for Mechanical Thromboembolectomy

2020

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The systemic or catheter-directed infusion of thrombolytics benefits patients with massive and probably submassive pulmonary embolism. However, the risk of bleeding may offset benefits in a substantial number of patients. Percutaneous mechanical thromboembolectomy is an alternative to thrombolysis in those patients with contraindications to the lytic therapy, also potentially a way to avoid systemic or catheter-directed infusion of the thrombolytic all together. The Inari FlowTriever System (Inari Medical Inc, CA, USA) is the first US FDA-cleared large-bore aspiration thrombectomy device with pulmonary embolism thrombectomy indication. This article is a review of the FlowTriever System, its clinical use, current supportive literates and future research directions.

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Catheter-directed therapies for pulmonary embolism: considerations for patients with patent foramen ovale

Cited by 2 publications

References 41 publications

Mechanical thrombectomy for pulmonary embolism in patients with patent foramen Ovale

Mechanical thrombectomy for pulmonary embolism in patients with patent foramen Ovale

FlowTriever System for Mechanical Thromboembolectomy

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