Catheter-directed thrombolysis for acute pulmonary embolism: Where do we stand?

Konstantinides, Stavros

doi:10.4103/lungindia.lungindia_115_17

Lung India

2017

DOI: 10.4103/lungindia.lungindia_115_17

|View full text |Cite

Catheter-directed thrombolysis for acute pulmonary embolism: Where do we stand?

Stavros Konstantinides

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2021

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Clinical profile and management of patients with acute pulmonary thromboembolism – a single centre, large observational study from India

et al. 2021

View full text Add to dashboard Cite

Acute Pulmonary Thromboembolism [PE] is associated with high mortality, similar to that of myocardial infarction and stroke. We studied the clinical presentation and management of PE in the Indian population. An analysis of 140 patients who presented with acute PE at a large volume center in India from June 2015 through December 2018 was performed. The mean age of our study population was 50 years with 59% being male. Comorbidities including Deep Vein Thrombosis [DVT], diabetes mellitus, hypertension, and Chronic Obstructive Pulmonary Disease [COPD] were present in 52.9%, 40%, 35.7% and 7.14% of patients, respectively. Out of 140 patients, 40 [28.6%] patients had massive PE, 36 [25.7%] sub-massive PE, and 64 [45.7%] had low risk PE. Overall, in-hospital mortality was 25.7%. Multivariate regression analysis found chronic kidney disease and PE severity to be the only independent risk factors. Thrombolysis was performed in 62.5% of patients with a massive PE and 63.9% of patients with a sub-massive PE. In the massive PE group, patients receiving thrombolytic therapy had lower mortality compared with patients who did not receive therapy[p=0.022], whereas this difference was not observed in patients in the sub-massive PE group. We conclude that patients with acute PE in India presented more than a decade earlier than our western counterparts, and it was associated with poor clinical outcomes. Thrombolysis was associated with significantly reduced in-hospital mortality in patients with massive PE.

show abstract

Clinical profile and management of patients with acute pulmonary thromboembolism – a single centre, large observational study from India

et al. 2021

View full text Add to dashboard Cite

show abstract

Efficacy and safety of hydro-mechanical defragmentation in intermediate- and high-risk pulmonary embolism

Abolghasemi

Ahmed

et al. 2021

Egypt Heart J

View full text Add to dashboard Cite

Background Pulmonary embolism (PE) is the third most common acute cardiovascular syndrome. Percutaneous catheter directed hydro-mechanical defragmentation (HMD) is one of the recommended treatment options for PE in patients with contraindications to thrombolytic therapy or failed systemic thrombolysis (ST). We aimed to identify the safety and outcomes of catheter directed HMD in patients with high-risk PE. This nonrandomized controlled trial enrolled all patients with confirmed diagnoses of high- and intermediate-high-risk PE from October 2019 till January 2021. Fifty patients were included and divided into two groups by the PE response team according to the presence or absence of a contraindication for ST. Group B (ST) consists of 25 patients and group A (HMD) of 25 patients who cannot receive ST. Results The two groups were comparable regarding baseline clinical characteristics with mean age 51 ± 13 years. In group A, systolic blood pressure (BP) and oxygen saturation increased after 24 h (p = 0.002) and 48 h (p < 0.001) compared to pre-HMD procedure. Mean pulmonary artery systolic pressure (PASP) and respiratory rate (RR) decreased after 48 h and at 30 days (p < 0.001) compared to pre-HMD procedure. The increase in systolic BP and oxygen saturation were significantly higher in HMD group compared with ST group after 48 h and at 30 days (p < 0.007). The decrease in PASP and RR was significantly higher in HMD group compared to ST group after 48 h and at 30 days (p < 0.001). Mortality rate at 30 days was 20% in HMD group compared to 32% in ST group. Conclusions Catheter directed HMD for high-risk and intermediate-high-risk PE is safe and effective with acceptable mortality Trial registration Clinical trial ID: NCT04099186.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Catheter-directed thrombolysis for acute pulmonary embolism: Where do we stand?

Cited by 2 publications

References 13 publications

Clinical profile and management of patients with acute pulmonary thromboembolism – a single centre, large observational study from India

Clinical profile and management of patients with acute pulmonary thromboembolism – a single centre, large observational study from India

Efficacy and safety of hydro-mechanical defragmentation in intermediate- and high-risk pulmonary embolism

Contact Info

Product

Resources

About