Catheter-related Bacteremia due to Lactobacillus rhamnosus in a Single-lung Transplant Recipient

Carretto, Edoardo; Barbarini, Daniela; Marzani, Federico Capra; Fumagalli, Paolo; Monzillo, Vincenzina; Marone, Piero; Emmi, V.

doi:10.1080/003655401317074653

Cited by 25 publications

(17 citation statements)

References 9 publications

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“…Like in our patient, the intra-abdominal abscess was possibly from bowel injury after the operation followed by translocation of intestinal microflora. Among transplant recipients, pneumonia, empyema, pyelonephritis, meningitis, catheter-associated, and surgical site infections have been reported [1,5,6,[10][11][12]. Lactobacillus bacteremia cases have almost 30 % of all-cause mortality within one month, in spite of the high clearance and low attributable mortality rate.…”

Section: Discussionmentioning

confidence: 94%

Carbapenem-resistant Lactobacillus intra-abdominal infection in a renal transplant recipient with a history of probiotic consumption

et al. 2016

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Here, we report a case of a 60-year-old renal transplant recipient who developed an intra-abdominal abscess which grew a carbapenem-resistant Lactobacillus casei. This is significant since it is the first report of a clinical isolate of Lactobacillus sp. that demonstrated both microbiological and clinical resistance to carbapenem use. Moreover, the probiotic supplement that the patient had taken also grew a similar organism raising the concern of probiotic associated infection in immunocompromised individual.

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Section: Discussionmentioning

confidence: 94%

Carbapenem-resistant Lactobacillus intra-abdominal infection in a renal transplant recipient with a history of probiotic consumption

et al. 2016

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“…They have very low pathogenicity to humans, and are widely used as probiotics. However, they are known to cause opportunistic infections in immunosuppressed patients [8], and cases of severe infection have been reported [2][3][4][5][6][7][8][9]. Cannon et al [2] analyzed more than 200 cases of infection by Lactobacillus spp., and the most frequent causative organisms were L. rhamnosus and L. casei.…”

Section: Discussionmentioning

confidence: 99%

“…They are often used for fermentation in the food industry, and are rarely pathogenic in humans [1]. However, it has been reported that, in immunosuppressed patients or those who have undergone organ transplantation [2][3][4][5][6][7][8][9], these bacilli cause critical infections such as sepsis and infectious endocarditis. Herein, we report a case of lung abscess and pleuritis caused by Lactobacillus rhamnosus in a patient who was not immunodeficient; this is considered to be the first such case reported in Japan.…”

Section: Introductionmentioning

confidence: 99%

Lung abscess and pleuritis caused by Lactobacillus rhamnosus in an immunocompetent patient

Shoji

Yoshida

Niki

2010

Journal of Infection and Chemotherapy

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“…Additionally, 92 human isolates (H), of which 58 are from sterile sites and 34 from commensal (mainly fecal, vaginal, and oral) human flora, were included. The human isolates were collected in hospitals or were obtained from culture collections or from authors who published clinical cases (2,3,6,9,19,21,23). The origin of the type strain of L. rhamnosus, LMG 6400, is not known.…”

Section: Methodsmentioning

confidence: 99%

Intraspecific Genotypic Characterization of Lactobacillus rhamnosus Strains Intended for Probiotic Use and Isolates of Human Origin

Vancanneyt¹,

Huys

Lefebvre³

et al. 2006

Appl Environ Microbiol

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A set of 118 strains of the species Lactobacillus rhamnosus was collected, including probiotic strains, research strains with potential probiotic properties, food starter cultures, and human isolates. The majority of the strains were collected from companies, hospitals, or culture collections or were obtained after contacting authors who reported clinical case studies in the literature. The present work aimed to reveal the genotypic relationships between strains of these diverse sources. All strains were initially investigated using fluorescent amplified fragment length polymorphism (FAFLP) with three different primer combinations. Numerical analysis of FAFLP data allowed (i) confirmation of the identification of all strains as members of L. rhamnosus and (ii) delineation of seven stable intraspecific FAFLP clusters. Most of these clusters contained both (potentially) probiotic strains and isolates of human origin. For each of the clusters, strains of different sources were selected for pulsed-field gel electrophoresis (PFGE) of macrorestriction fragments obtained with the enzymes NotI and AscI. Analysis of PFGE data indicated that (i) some (potentially) probiotic strains were indistinguishable from other probiotic strains, suggesting that several companies may use duplicate cultures of the same probiotic strain, and (ii) in a number of cases human isolates from sterile body sites were indistinguishable from a particular probiotic strain, suggesting that some of these isolates may be reisolations of commercial strains.Lactobacillus species are members of the commensal microflora in the oral cavity and the gastrointestinal and genitourinary system in humans and animals and are usually considered nonpathogenic (1). Selected strains of some Lactobacillus species are being used as probiotics and are claimed to influence the health of the host in a beneficial manner (10). To a very limited extent, strains belonging to the same Lactobacillus species as those used in probiotic applications have also been isolated from clinical specimens and have been associated with rare cases of endocarditis, meningitis, deep abscesses, and bacteremia (1, 5, 11). It should be noted that in these types of infections underlying disease or immunosuppression is a common feature and that infection in previously healthy humans is extremely rare.Among the lactobacilli, strains of Lactobacillus rhamnosus are commonly used as probiotics including the GG (GorbachGoldin) strain, which is one of the most widely used and welldocumented probiotics (13, 25). On the other hand, L. rhamnosus has also been reported as one of the most common Lactobacillus taxa in human clinical cases (5). Harty et al. (8,9) identified possible virulence factors in L. rhamnosus endocarditis strains compared to laboratory or oral isolates. Furthermore, L. rhamnosus strains have been shown to produce enzymes enabling the breakdown of glycoproteins and synthesis or lysis of fibrin clots (18).Aggregate epidemiologic studies have not found a link between the number of clinica...

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Catheter-related Bacteremia due to Lactobacillus rhamnosus in a Single-lung Transplant Recipient

Cited by 25 publications

References 9 publications

Carbapenem-resistant Lactobacillus intra-abdominal infection in a renal transplant recipient with a history of probiotic consumption

Carbapenem-resistant Lactobacillus intra-abdominal infection in a renal transplant recipient with a history of probiotic consumption

Lung abscess and pleuritis caused by Lactobacillus rhamnosus in an immunocompetent patient

Intraspecific Genotypic Characterization of Lactobacillus rhamnosus Strains Intended for Probiotic Use and Isolates of Human Origin

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