Catheter-related bloodstream infection caused by Kodamaea ohmeri : A case report and literature review

Kanno, Yoshihiro; Wakabayashi, Yoshitaka; Ikeda, Mahoko; Tatsuno, Keita; Misawa, Yoshiki; Sato, Tomoaki; Yanagimoto, Shintaro; Okugawa, Shu; Moriya, Kyoji; Yotsuyanagi, Hiroshi

doi:10.1016/j.jiac.2017.01.003

Cited by 18 publications

(26 citation statements)

References 30 publications

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“…No additional studies were found during the hand‐screening of the included articles' references. Finally, 35 met the present study's inclusion criteria 3,4,7–39 . The review process is graphically presented in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Among the 35 studies on K ohmeri infections, 30 (85.7%) reported fungemias, accounting for 36 patients out of 44 (81.8%) in total 3,4,7–34 . A concomitant infection was present in 22.2% (8 out of 36 fungemias), namely infective endocarditis (IE) in 11.1% (4 cases), 31–34 skin and soft tissue infection (SSTI) in 5.6% (2 cases), 16,21 disseminated infection with involvement of the spleen, urinary tract and lower respiratory tract in 2.8% (1 case), 8 and lower respiratory tract infection in 2.8% (1 case) 29 .…”

Section: Resultsmentioning

confidence: 99%

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Kodamaea ohmeri infections in humans: A systematic review

Ιωάννου

Papakitsou

2020

Mycoses

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Summary Background Kodamaea ohmeri, previously known as Pichia ohmeri or Yamadazyma ohmeri, belongs to the Saccharomycetaceae family and the Ascomycetae class, is the telomorphic form of C guilliermondii var. membranaefaciens and is frequently mistaken for Candida, as they belong to the same family. It has been isolated from environmental sources, such as sand, pools, seawater and fruits, while the last decades it is recognised as a rare pathogen that causes life‐threatening infections in humans. The purpose of this study was to systemically review all published cases of K ohmeri infections in the literature and describe the epidemiology, microbiology, antimicrobial susceptibility, treatment and outcomes of these infections in humans. Methods Systematic review of PubMed (through 27th December 2019) for studies providing epidemiological, clinical, microbiological as well as treatment data and outcomes of K ohmeri infections. Results A total of 35 studies, containing data of 44 patients, were included in the analysis. The most common K ohmeri infections were those of the bloodstream, infective endocarditis and onychomycosis. Previous antibiotic use, presence of a central venous catheter, parenteral nutrition and cancer were very common among patients. Mortality was high in the case of fungemias but low for other types of infections. Amphotericin B and fluconazole are the most common agents used for treatment, even though alarming MICs for fluconazole were noted. Conclusions This systematic review thoroughly describes infections by K ohmeri and provides information on their epidemiology, clinical presentation, microbiology, antibiotic resistance patterns, treatment and outcomes.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Kodamaea ohmeri infections in humans: A systematic review

Ιωάννου

Papakitsou

2020

Mycoses

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“…There have been 88 reports of infection with K. ohmeri described in the literature. Among them, 76 patients presented with fungaemia and the remaining presented with peritonitis (three patients), endocarditis (four patients), urinary tract infection (one patient), polymicrobial wound infection (one patient) and oral ulcer (three patients). In the present case, the lesion was exclusively limited to the site of the wound without systemic involvement.…”

Section: Discussionmentioning

confidence: 99%

“…Diabetes mellitus, malignant tumour, intravenous drug use, cardiac prosthetic valves, chronic kidney diseases and premature infants are risk factors for invasive infections due to K. ohmeri . Some cases of fungaemia resulted from catheter‐related issues, cellulitis or burned skin, suggesting that breakdown of the mucocutaneous barrier is a significant risk factor for systemic K. ohmeri infection. In this case, our patient was at risk of invasive infections because she had rheumatoid arthritis and received oral low‐dose methylprednisolone.…”

Section: Discussionmentioning

confidence: 99%

“…K. ohmeri is an unusual pathogen that causes mycosis, although it is commonly used for its fermentation properties in the food industry in pickles, rinds and fruits . Recently, it has been identified as a cause of fungaemia, peritonitis, endocarditis, funguria and cellulitis . It usually affects patients with underlying conditions, including prematurity, immunosuppression, prolonged hospitalization, prosthetic valves and central venous lines or other medical devices, such as peritoneal catheters.…”

Section: Introductionmentioning

confidence: 99%

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Subcutaneous granuloma caused by Kodamaea ohmeri in an immunocompromised patient in China

Yan

Gao

et al. 2019

Aust J Dermatology

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We present a case of subcutaneous granuloma caused by Kodamaea ohmeri and describe the histopathological characteristics and skin lesions caused by this pathogen. A 55-year-old woman, with a history of rheumatoid arthritis, presented with red, painless plaque on her forehead, persistent for 3 months; based on the histopathological and mycological findings and gene sequencing, the patient was diagnosed with subcutaneous granuloma caused by K. ohmeri. This report highlights that early identification and diagnosis and optimal regimens are vital in the management of this intractable infection.

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Candida pseudoglaebosa and Kodamaea ohmeri are capable of degrading alkanes in the presence of heavy metals

et al. 2019

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The aim of this study was to examine four strains of two yeast species in relation to their capability for assimilating alkanes in the presence of heavy metals (HMs). The four strains tested were Candida pseudoglaebosa ENCB‐7 and Kodamaea ohmeri ENCB‐8R, ENCB‐23, and ENCB‐VIK. Determination was made of the expression of CYP52 genes involved in alkane hydroxylation. When exposed to Cu2+, Zn2+, Pb2+, Cd2+, and As3+ at pH 3 and 5, all four strains could assimilate several n‐alkanes having at least six carbon atoms. The three K. ohmeri strains could also utilize branched alkanes, cycloalkanes, and n‐octanol as sole carbon sources. Kinetic assays demonstrated greater biomass production and specific growth of the yeasts exposed to long‐chain n‐alkanes. Fragments of paralogous CYP52 genes of C. pseudoglaebosa ENCB‐7 and K. ohmeri ENCB‐23 were amplified, sequenced, and phylogenetically evaluated. Reverse‐transcription polymerase chain reaction revealed that n‐nonane and n‐decane induced to CpCYP52‐G3, CpCYP52‐G9, and CpCYP52‐G10. KoCYP52‐G3 was induced with n‐decane and n‐octanol. Also, CpCYP52‐G3 and CpCYP52‐G9 were induced by glucose. In conclusion, C. pseudoglaebosa and K. ohmeri were able to degrade several alkanes in the presence of HMs and under acidic conditions. These yeasts harbor paralogous alkane‐induced CYP52 genes, which display different profiles of transcriptional expression.

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Catheter-related bloodstream infection caused by Kodamaea ohmeri : A case report and literature review

Cited by 18 publications

References 30 publications

Kodamaea ohmeri infections in humans: A systematic review

Kodamaea ohmeri infections in humans: A systematic review

Subcutaneous granuloma caused by Kodamaea ohmeri in an immunocompromised patient in China

Candida pseudoglaebosa and Kodamaea ohmeri are capable of degrading alkanes in the presence of heavy metals

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