Catheter-related bloodstream infection management in patients receiving home parenteral nutrition: An observational cohort study

Gompelman, Michelle; Causevic, Erna; Bleeker‐Rovers, Chantal P.; Wanten, Geert

doi:10.1016/j.clnesp.2022.06.003

Cited by 7 publications

(4 citation statements)

References 37 publications

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“…Catheter salvage was defined as successful when no relapse of infection occurred within 30 days after the start of antimicrobial therapy in a patient in whom a CVC remained in situ 19 . Relapse infection was defined as an infection caused by the same causative pathogen, with an identical antibiogram within 30 days of the first date of the previous CRBSI after resolution of the clinical and biochemical signs of infection after a course of antimicrobial therapy 19,22 …”

Section: Methodsmentioning

confidence: 99%

“…19 Relapse infection was defined as an infection caused by the same causative pathogen, with an identical antibiogram within 30 days of the first date of the previous CRBSI after resolution of the clinical and biochemical signs of infection after a course of antimicrobial therapy. 19,22 Current standard care…”

Section: Journal Of Parenteral and Enteral Nutrition | 487mentioning

confidence: 99%

“…Our definition of a successful salvage (cure of S aureus bacteremia after catheter salvage), was based on the clinical condition of the patient and extracted from previous literature. 19,22 In this definition, it is assumed that bacteremia is cured 30 days after diagnosis and treatment of S aureus bacteremia, and no clinical and biochemical signs of infection are detected at that time. However, various definitions are used, as mentioned.…”

Section: Definition Of Successmentioning

confidence: 99%

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Catheter salvage or removal in catheter‐related bloodstream infections with Staphylococcus aureus in children with chronic intestinal failure receiving home parenteral nutrition and the use of prophylactic taurolidine catheter lock solution: A descriptive cohort study

Demirok,

Illy,

Nagelkerke

et al. 2024

J Parenter Enteral Nutr

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BackgroundChildren with chronic IF require long‐term home parenteral nutrition (HPN), administered through a central venous catheter. Catheter‐related bloodstream infection (CRBSI) with Staphylococcus aureus is known to be a serious infection with a high mortality rate and risk of complications. A standardized protocol on the management of S aureus CRBSIs in children receiving HPN is lacking. The aim of this study is to evaluate the effectiveness and safety of the current management in an HPN expertise center in the Netherlands.MethodsWe performed a retrospective descriptive cohort study between 2013 and 2022 on children 0–18 years of age with chronic IF requiring long‐term HPN. Our primary outcomes were the incidence of S aureus CRBSI per 1000 catheter days, catheter salvage attempt rate, and successful catheter salvage rate. Our secondary outcomes included complications and mortality.ResultsA total of 74 patients (39 male; 53%) were included, covering 327.8 catheter years. Twenty‐eight patients (38%) had a total of 52 S aureus CRBSIs, with an incidence rate of 0.4 per 1000 catheter days. The catheter salvage attempt rate was 44% (23/52). The successful catheter salvage rate was 100%. No relapse occurred, and no removal was needed after catheter salvage. All complications that occurred were already present at admission before the decision to remove the catheter or not. No patients died because of an S aureus CRBSI.ConclusionCatheter salvage in S aureus CRBSIs in children receiving HPN can be attempted after careful consideration by a multidisciplinary team in an HPN expertise center.

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Section: Methodsmentioning

confidence: 99%

Section: Journal Of Parenteral and Enteral Nutrition | 487mentioning

confidence: 99%

Section: Definition Of Successmentioning

confidence: 99%

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Catheter salvage or removal in catheter‐related bloodstream infections with Staphylococcus aureus in children with chronic intestinal failure receiving home parenteral nutrition and the use of prophylactic taurolidine catheter lock solution: A descriptive cohort study

Demirok,

Illy,

Nagelkerke

et al. 2024

J Parenter Enteral Nutr

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“…Patients with IF require intravenous supplementation to maintain health and/or growth ( 2 ). Although parenteral nutrition is lifesaving in IF, long-term application is often associated with severe complications such as liver disease and bloodstream infections ( 3 ). Because of the development of dilated loops and reduced peristalsis small intestinal bacterial overgrowth (SIBO) may occur ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Dysbiosis and reduced small intestinal function are required to induce intestinal insufficiency in mice

Berlin

Barrantes

Reiner

et al. 2023

American Journal of Physiology-Gastrointestinal and Liver Physi

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Extensive bowel resection can lead to short bowel syndrome and intestinal failure. Resection-induced dysbiosis may be related to the specific anatomic site of resection and influences the disease progression. While patients with end-jejunostomy are at high risk for intestinal failure, preservation of the ileocecal valve and colon counteracts this risk. The present study investigated the role of the cecum in maintaining microbial homeostasis after different types of small bowel resection. Male C57BL6/J mice were anesthetized by intraperitoneal injection of ketamine/xylazine and received extended ileocecal resection (extended ICR), limited ileocecal resection (limited ICR) or mid small bowel resection (SBR). Stool samples were collected before surgery and between postoperative days 2-7, for 16S rRNA gene sequencing. Only extended ICR, but neither limited ICR nor SBR, induced intestinal insufficiency. α-diversity was reduced in both ICR variants, but not after SBR. All resections resulted in an increase in Proteobacteria. Pathobionts, such as Clostridia, Shigella, and Enterococcus, increased after SBR while Muribaculaceae, Lactobacillus, and Lachnospiraceae decreased. Limited ICR resulted in an increase of members of the Clostridium sensu stricto group, Terrisporobacter and Enterococcus and a decrease of Muribaculaceae. The increase of Enterococcus was even more pronounced after extended ICR while Muribaculaceae and Akkermansia were dramatically reduced. Both ICR variants caused a decrease of steroid biosynthesis and glycosaminoglycan degradation associated pathways, suggesting altered bile acid transformation and mucus utilization

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Salvage strategy for long-term central venous catheter-associated Staphylococcus aureus infections in children: a multi-centre retrospective study in France

Devautour,

Poey,

Lagier

et al. 2024

Journal of Hospital Infection

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Catheter-related bloodstream infection management in patients receiving home parenteral nutrition: An observational cohort study

Cited by 7 publications

References 37 publications

Catheter salvage or removal in catheter‐related bloodstream infections with Staphylococcus aureus in children with chronic intestinal failure receiving home parenteral nutrition and the use of prophylactic taurolidine catheter lock solution: A descriptive cohort study

Catheter salvage or removal in catheter‐related bloodstream infections with Staphylococcus aureus in children with chronic intestinal failure receiving home parenteral nutrition and the use of prophylactic taurolidine catheter lock solution: A descriptive cohort study

Dysbiosis and reduced small intestinal function are required to induce intestinal insufficiency in mice

Salvage strategy for long-term central venous catheter-associated Staphylococcus aureus infections in children: a multi-centre retrospective study in France

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