Catheter-related Infections by Hansenula anomala in Children

Abstract

During August and September, 1992, we experienced 4 cases of Hansenula anomala (H. anomala, synonym Pichia anomala) fungemia in immunocompromised patients. Two patients had been suffering from a malignant disease, 3 of them had received broad-spectrum antibiotics and a central venous catheter (CVC) had been inserted in all of them. H. anomala was isolated as the sole pathogen from all 4 patients. Three of them responded favorably to fluconazole after withdrawal of the catheter, but one failed. H. anomala should be considered as a possible cause of catheter-related infections.

Fungal endocarditis in critically ill children

“…Candida albicans was the most common pathogen (4/5) in our series. Recent reports suggest either increased recognition or increased frequency of infection with Hansenula anomala as in one of our patients [22]. The incidence of positive blood cultures in Aspergillus spp.…”

Part 11: Pediatric Basic Life Support and Cardiopulmonary Resuscitation Quality

“…Molecular epidemiologic studies suggested a common source. An additional seven outbreaks of C. pelliculosa (P. anomala) fungemia in either neonatal or pediatric intensive care units, affecting patients ranging in number from 2 to 24 (4,7,59,67,69,102,111), and two outbreaks involving adult patients (4 and 8 patients, respectively) (37, 54) have been reported in the literature. In several of these outbreaks, analyses of the epidemic curve and molecular epidemiologic markers suggested a common exogenous source for C. pelliculosa (P. anomala) fungemia.…”

Emerging Fungal Infections

“…The exact reasons for these changes are not completely clear. In some cases, they may be related to specific medical interventions, such as antifungal prophylaxis [10] and the use of medical devices [11][12][13] . However, in the majority of cases, they seem to be a consequence of changes in the host, with more severe immunosuppression [14] .…”