Catheterization of the common umbilical vein for chronic fetal lamb studies.

Young, Warren; Rk, Creasy; Rudolph, Abraham M.

doi:10.1152/jappl.1974.37.4.620

Cited by 18 publications

(6 citation statements)

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“…A midlinc abdominal incision was made, the pregnant uterine horn was exposed, and small hysterotomies were made to ex pose fetal parts. Catheters were inserted into the common umbilical vein (16), the amniotic cavity, and the fetal hind limb artery and vein from where they were advanced into the descending aorta and the inferior vena cava, respectively. The common um bilical artery was isolated by a retroperitoneal ap proach and a specially constructed, precalibrated electromagnetic flow transducer (2) was placed around it.…”

Section: Methodsmentioning

confidence: 99%

Effects of Pharmacologic Agents on Umbilical Blood Flow in Fetal Lambs in utero

Berman¹,

Goodlin²,

Heymann³

et al. 1978

Neonatology

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We studied the effects of pharmacologic agents on umbilical blood flow and umbilical-placental vascular resistance in 18 fetal lambs in utero. Three groups of drugs were identified: the first had no effect on umbilical blood flow or umbilical-placental vascular resistance; the second altered umbilical blood flow secondary to changes in heart rate and placental perfusion pressure, but did not change umbilical-placental vascular resistance; the third decreased umbilical blood flow and increased umbilical-placental vascular resistance. The studies suggest mechanisms by which umbilical blood flow is regulated in the fetal lamb.

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Section: Methodsmentioning

confidence: 99%

Effects of Pharmacologic Agents on Umbilical Blood Flow in Fetal Lambs in utero

Berman¹,

Goodlin²,

Heymann³

et al. 1978

Neonatology

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“…Polyvinyl catheters were placed in both fetal femoral arteries and veins via the tarsal vessels. An amniotic catheter was sutured to one of the fetal hind limbs for administration of antibiotics, and the fetal common umbilical vein was catheterised (Young et al 1974). Growth catheters were sutured around each side of the fetal chest from the sternum to the spine to measure change in fetal girth (Mellor & Murray 1982, Harding 1997.…”

Section: Animal Preparationmentioning

confidence: 99%

Metabolic effects of IGF-I in the growth retarded fetal sheep

Jensen¹,

Harding²,

Bauer³

et al. 1999

Journal of Endocrinology

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It has been shown that IGF-I has an anabolic effect in the normal fetus. However, there is evidence to suggest that there may be IGF-I resistance in the growth retarded fetus. Therefore, we investigated the effects of acute IGF-I infusion to chronically catheterised fetal sheep. At 128 days gestation, fetuses underwent a 4 h infusion of IGF-I (50 µg/kg/h). Three groups of animals were studied. Nine normally grown fetuses were studied as controls. Embolised animals (n=8) received microspheres into the uterine vasculature, and animals with spontaneous intra-uterine growth retardation (IUGR animals) (n=6) were fetuses found at post mortem to be spontaneously growth restricted.The effects of IGF-I infusion on feto-placental carbohydrate and protein metabolism were similar in our control group to previous similar experiments. IGF-I infusion decreased fetal blood glucose, oxygen, urea and aminonitrogen concentrations, and inhibited placental lactate production. The same fetal blood metabolite concentrations also fell during IGF-I infusion in the embolised fetuses, but the effect on placental lactate production was not seen. The only effect of IGF-I infusion in the spontaneous IUGR animals was a fall in fetal blood amino-nitrogen concentrations. We conclude that fetal IGF-I infusion does not have the same anabolic effects in the growth retarded fetus as the normal fetus. In addition, the effects of IGF-I were different in the two growth retarded groups. Our data support previous evidence that the growth retarded fetus has altered IGF-I sensitivity, and this may vary depending on the cause, severity and duration of growth retardation.

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“…The surgical proce dures were carried out under aseptic conditions, and spinal anesthesia with supplemental thiopental was used. The surgical techniques for placement of the electromagnetic flow transducer and the common umbilical venous catheter have been reported previous ly (1,8). Catheters were also placed in the fetal distal aorta (representative of umbilical arterial blood), amniotic cavity and maternal hindlimb artery.…”

Section: Methodsmentioning

confidence: 99%

“…By combining techniques for measuring common umbilical arterial blood flow (1), catheterization of the common umbil ical vein (8), and an accurate and rapid method for measuring oxygen content in small samples of blood (3), it is now possible to measure serially fetal oxygen uptake in.the undisturbed chronically instrumented sheep.…”

mentioning

confidence: 99%

Oxygen Consumption of the Fetal Sheep in utero

Parer¹

1978

Neonatology

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Oxygen consumption was measured in 8 chronically instrumented fetal sheep by a combination of recently introduced techniques. Umbilical blood flow was measured by an electromagnetic flow transducer placed around the common portion of the umbilical artery. Blood representative of that in the umbilical artery was obtained from the distal aorta. The common portion of the umbilical vein was catheterized by direct puncture of the vessel at the base of the umbilicus. An accurate micromethod was used to measure oxygen content of blood from the umbilical vessels, and oxygen consumption was calculated by application of the Fick principle. The mean fetal oxygen consumption was 7.9 ± 1.8 ml O₂/min/kg fetus.

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Catheterization of the common umbilical vein for chronic fetal lamb studies.

Cited by 18 publications

References 0 publications

Effects of Pharmacologic Agents on Umbilical Blood Flow in Fetal Lambs <i>in utero</i>

Effects of Pharmacologic Agents on Umbilical Blood Flow in Fetal Lambs <i>in utero</i>

Metabolic effects of IGF-I in the growth retarded fetal sheep

Oxygen Consumption of the Fetal Sheep <i>in utero</i>

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