Cathodal transcranial direct current stimulation of the visual cortex in the prophylactic treatment of migraine

Antal, Andrea; Kriener, Naomi; Lang, N.; Boros, Klára; Paulus, Walter

doi:10.1177/0333102411399349

Cited by 169 publications

(168 citation statements)

References 29 publications

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“…tDCS is currently being investigated as a therapeutic instrument for varied neurological conditions, which includes major depression 14,15 , posttraumatic stress disorder 16 , craving for food 17 , marijuana 18 , alcohol 19 and smoking 20 , as well as pain 21 , tinnitus 22 , migraine 23 , epilepsy 24 , Parkinson's disease 25,26 , stroke rehabilitation 27,28 and cognitive dysfunction 6,29 . Table 1 shows the evidence-based tDCS electrode montages to be used as treatment for different clinical conditions.…”

Section: Representative Resultsmentioning

confidence: 99%

Simultaneous EEG Monitoring During Transcranial Direct Current Stimulation

Schestatsky

Morales-Quezada

Fregni

2013

JoVE

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Transcranial direct current stimulation (tDCS) is a technique that delivers weak electric currents through the scalp. This constant electric current induces shifts in neuronal membrane excitability, resulting in secondary changes in cortical activity. Although tDCS has most of its neuromodulatory effects on the underlying cortex, tDCS effects can also be observed in distant neural networks. Therefore, concomitant EEG monitoring of the effects of tDCS can provide valuable information on the mechanisms of tDCS. In addition, EEG findings can be an important surrogate marker for the effects of tDCS and thus can be used to optimize its parameters. This combined EEG-tDCS system can also be used for preventive treatment of neurological conditions characterized by abnormal peaks of cortical excitability, such as seizures. Such a system would be the basis of a non-invasive closed-loop device. In this article, we present a novel device that is capable of utilizing tDCS and EEG simultaneously. For that, we describe in a step-by-step fashion the main procedures of the application of this device using schematic figures, tables and video demonstrations. Additionally, we provide a literature review on clinical uses of tDCS and its cortical effects measured by EEG techniques.

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Section: Representative Resultsmentioning

confidence: 99%

Simultaneous EEG Monitoring During Transcranial Direct Current Stimulation

Schestatsky

Morales-Quezada

Fregni

2013

JoVE

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“…However, inhibitory low frequency rTMS over the vertex had no superior therapeutic effect to sham stimulation, 151 and cathodal (inhibitory) tDCS over the occipital cortex had no signifi cant preventive effect on migraine attacks , although the latter intervention did reduce attack intensity compared with placebo. 152 By contrast, in a pilot trial designed to assess an alternative hypothesis-that the visual cortex is not hyperexcitable per se, but, rather, insufficiently activated at baseline (as described above 87 )-anodal (facilitatory) tDCS over the occipital cortex significantly decreased attack frequency and intensity when used as preventive therapy in patients with migraine. 150 The challenge for future research, therefore, lies in identification of the precise anatomical structures and functional networks involved in migraine, and determi nation of which pharmacological and nonpharmacologi cal interventions can optimally modulate the function of these areas and thereby improve temporal information processing.…”

Section: Prospects For Clinical Researchmentioning

confidence: 99%

Altered processing of sensory stimuli in patients with migraine

et al. 2014

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| Migraine is a cyclic disorder, in which functional and morphological brain changes fluctuate over time, culminating periodically in an attack. In the migrainous brain, temporal processing of external stimuli and sequential recruitment of neuronal networks are often dysfunctional. These changes reflect complex CNS dysfunction patterns. Assessment of multimodal evoked potentials and nociceptive reflex responses can reveal altered patterns of the brain's electrophysiological activity, thereby aiding our understanding of the pathophysiology of migraine. In this Review, we summarize the most important findings on temporal processing of evoked and reflex responses in migraine. Considering these data, we propose that thalamocortical dysrhythmia may be responsible for the altered synchronicity in migraine. To test this hypothesis in future research, electrophysiological recordings should be combined with neuroimaging studies so that the temporal patterns of sensory processing in patients with migraine can be correlated with the accompanying anatomical and functional changes.

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“…Indeed, most of the public, are aware of electroconvulsive therapy (ECT), often referred to as "electroshock", and its deleterious effects on cognition (e.g., amnesia) [1]. However, in the new millennium a burst of studies using transcranial electric stimulation (TES) have demonstrated that the delivery of a low current of electricity to well-defined brain regions can positively a ect human mental health and well-being in areas such as pain [2], migraines [3] and psychiatric illnesses [4]. The aim of the current paper is to introduce TES methods within the framework of cognitive enhancement, a topic with important implications for translational neuroscience.…”

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confidence: 99%

Using transcranial electrical stimulation to enhance cognitive functions in the typical and atypical brain

Kadosh

2013

Translational Neuroscience

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Transcranial electrical stimulation (TES) includes methods such as transcranial direct current stimulation, transcranial random noise stimulation, and transcranial alternating current stimulation. These methods provide novel ways of enhancing human cognitive abilities for restorative purposes, or for general cognitive enhancement, by modulating neuronal activity. I discuss here the basic principles behind these methods and provide some illustrations of their efficacy in cognitive enhancement in those with typical and atypical brain function. Next, I outline some future directions for research that are have been largely neglected, such as the issue of individual differences, cognitive side effects, the efficacy of TES for use with healthy elderly populations, children with atypical development, and sports. The results observed thus far with TES as well as its future possibilities have significant implications for both basic and translational neuroscience.

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Cathodal transcranial direct current stimulation of the visual cortex in the prophylactic treatment of migraine

Abstract: Our results suggest that the application of cathodal stimulation over the V1 might be an effective prophylactic therapy in migraine, at least with regard to pain control.

Cited by 169 publications

References 29 publications

Simultaneous EEG Monitoring During Transcranial Direct Current Stimulation

Simultaneous EEG Monitoring During Transcranial Direct Current Stimulation

Altered processing of sensory stimuli in patients with migraine

Using transcranial electrical stimulation to enhance cognitive functions in the typical and atypical brain

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