Cation Tuning of Supramolecular Gel Properties: A New Paradigm for Sustained Drug Delivery

Ramin, M.; Sindhu, Kotagudda Ranganath; Appavoo, Ananda; Oumzil, Khalid; Grinstaff, Mark W.; Chassande, Olivier; Barthélémy, Philippe

doi:10.1002/adma.201605227

Cited by 62 publications

(52 citation statements)

References 54 publications

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“…1A). Based on primary investigations, gel formation from this molecule in 0.9% sodium chloride aqueous solution was performed using the same protocol as previously described 28,30,31 . Identical formulation steps were applied in the case of culture medium DMEM.…”

Section: Resultsmentioning

confidence: 99%

“…nucleotide lipid biomaterial ink formulation. The amphiphilic thymidine-based nucleotide lipid bioconjugate diC 16 dT reported in this study was synthesised by our team 28,30,31 , and hydrogel formulations were adapted from our previous studies.…”

Section: Methodsmentioning

confidence: 99%

“…In this context, we hypothesised that low molecular weight gelators (LMWGs) could lead to non-toxic nucleotide lipid-based hydrogels suitable for biofabrication applications. As a supramolecular strategy involving biomolecules, this approach aims at developing biocompatible hydrogels under mild conditions 28 . Among LMWGs, bioinspired amphiphiles such as nucleotide lipids (NLs) and glycosyl-nucleoside lipids (GNLs) display interesting properties due to their chemical structure [28][29][30][31] .…”

mentioning

confidence: 99%

“…As a supramolecular strategy involving biomolecules, this approach aims at developing biocompatible hydrogels under mild conditions 28 . Among LMWGs, bioinspired amphiphiles such as nucleotide lipids (NLs) and glycosyl-nucleoside lipids (GNLs) display interesting properties due to their chemical structure [28][29][30][31] . Composed of natural moieties such as nucleosides/nucleotides, sugars and aliphatic chains, these low molecular weight systems exhibit good biocompatibility, biostability and biodegradability.…”

mentioning

confidence: 99%

“…As a proof of concept, we demonstrated that a nucleotide lipid-based hydrogel could be used as a novel BmI or bioink for biofabrication. We have studied the physicochemical and biological properties of a bioconjugate 28,31 , including its rheological properties, printability in a culture medium, cell viability and in vivo tolerance.…”

mentioning

confidence: 99%

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Nucleotide lipid-based hydrogel as a new biomaterial ink for biofabrication

Dessane

Smirani

Bouguéon

et al. 2020

Sci Rep

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One of the greatest challenges in the field of biofabrication remains the discovery of suitable bioinks that satisfy physicochemical and biological requirements. Despite recent advances in tissue engineering and biofabrication, progress has been limited to the development of technologies using polymer-based materials. Here, we show that a nucleotide lipid-based hydrogel resulting from the self-assembly of nucleotide lipids can be used as a bioink for soft tissue reconstruction using injection or extrusion-based systems. To the best of our knowledge, the use of a low molecular weight hydrogel as an alternative to polymeric bioinks is a novel concept in biofabrication and 3D bioprinting. Rheological studies revealed that nucleotide lipid-based hydrogels exhibit suitable mechanical properties for biofabrication and 3D bioprinting, including i) fast gelation kinetics in a cell culture medium and ii) shear moduli and thixotropy compatible with extruded oral cell survival (human gingival fibroblasts and stem cells from the apical papilla). This polymer-free soft material is a promising candidate for a new bioink design.Biofabrication is a growing field in regenerative medicine and represents a promising tool for the construction of complex 3D structures 1-4 . Several approaches 5,6 allow 3D-bioprinted construction to be achieved, with three main techniques: inkjet, laser and extrusion-based bioprinting 7 . Extrusion-based bioprinting (EBB) is one of the most widespread tools used in biofabrication, mainly due to its capacity to build large-volume constructs such as tissue or organ equivalents 5,8 . This technique offers a wide range of opportunities because it is suitable for various polymeric materials including scaffold-based (hydrogels, microcarriers, decellularised matrix components) as well as scaffold-free (cell aggregates) materials 5 .Murphy et al. 1 presented their concept of the "ideal material", which needs to display several features, including printability, biocompatibility, good degradation kinetics, and favourable structural and mechanical properties, as well as material biomimicry. According to recent definitions 9 , a bioink can be defined as "a formulation of cells that is suitable to be processed by an automated biofabrication technology". The presence of cells is a key element, and formulations that do not contain cells or involve the seeding of cells after printing do not qualify as bioinks. The term "biomaterial ink" (BmI) is then used. Consequently, this distinction will be used throughout our work.Hydrogels are commonly used for the formulation of bioinks or BmIs and seem to be promising biomaterials because they are affordable, are easy to handle and can mimic the extracellular matrix 10 . Initial approaches of EBB used synthetic polymers such as polyethylene glycol (PEG) or gelatine methacrylate (GelMA) as scaffold materials, but they suffered from poor biological properties 11 . As an alternative, natural polymers derived from fibrous proteins or peptides have been developed due to their intr...

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Nucleotide lipid-based hydrogel as a new biomaterial ink for biofabrication

Dessane

Smirani

Bouguéon

et al. 2020

Sci Rep

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Ion Clusters‐Driven Strong and Acid/Alkali/ Freezing‐Tolerant Conductive Hydrogels for Flexible Sensors in Extreme Environments

Lyu,

Guo,

Lin

et al. 2023

Adv Funct Materials

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Supramolecular polymer hydrogels, exhibiting wide applications in flexible sensing, wearable electronics, artificial skin, etc., often require complex molecule and component design to adapt extreme environments. Most supramolecular polymer hydrogels currently, however, are unable to satisfy the harsh demands ascribed to their poor mechanical properties and chemical stability. Herein, this study demonstrates a novel strategy to fabricate superstrong polyvinyl alcohol (PVA) hydrogels with densely supramolecular polymer networks (SPNs) and complexation, induced by simple deprotonation and reconfiguration of ion clusters (ICs). Such strategy enables the PVA hydrogels with high strength (9.64 ± 0.5 MPa), compressibility, and recoverability (load objects over ≈10000 times more than its weight), resistance to various solvents, freezing tolerance (keep flexible and conductive even at −50 °C) and many other performances. Notably, the properties of resultant hydrogels surpass majority reported, tackling a long‐standing dilemma both mechanical properties and stability for PVA hydrogels. A proof‐of‐concept spider robot is assembled by 3D printed model, which achieves successfully signal acquisition in different extreme conditions. In this study the multifunctional PVA hydrogels are envisioned as a simple and universal strategy for sensors in various conditions, which is significant for the exploration in extreme environments that are not easily accessible to humans, such as the North and South Poles and solvent leakage area.

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Lipid and Nucleic Acid Chemistries: Combining the Best of Both Worlds to Construct Advanced Biomaterials

et al. 2018

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Hybrid synthetic amphiphilic biomolecules are emerging as promising supramolecular materials for biomedical and technological applications. Herein, recent progress in the field of nucleic acid based lipids is highlighted with an emphasis on their molecular design, synthesis, supramolecular properties, physicochemical behaviors, and applications in the field of health science and technology. In the first section, the design and the study of nucleolipids are in focus and then the glyconucleolipid family is discussed. In the last section, recent contributions of responsive materials involving nucleolipids and their use as smart drug delivery systems are discussed. The supramolecular materials generated by nucleic acid based lipids open new challenges for biomedical applications, including the fields of medicinal chemistry, biosensors, biomaterials for tissue engineering, drug delivery, and the decontamination of nanoparticles.

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Cation Tuning of Supramolecular Gel Properties: A New Paradigm for Sustained Drug Delivery

Cited by 62 publications

References 54 publications

Nucleotide lipid-based hydrogel as a new biomaterial ink for biofabrication

Nucleotide lipid-based hydrogel as a new biomaterial ink for biofabrication

Ion Clusters‐Driven Strong and Acid/Alkali/ Freezing‐Tolerant Conductive Hydrogels for Flexible Sensors in Extreme Environments

Lipid and Nucleic Acid Chemistries: Combining the Best of Both Worlds to Construct Advanced Biomaterials

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